载脂蛋白E基因多态性与脑梗死继发癫痫及血脂水平的相关性  

Association between apolipoprotein E gene polymorphisms and epilepsy secondary to cerebral infarction and lipid levels

作　　者：董露露 凌静[1] 杨旭萍 邹素兰[1] 胡楠[1] 蒋艳[1] DONG Lulu;LING Jing;YANG Xuping;ZOU Sulan;HU Nan;JIANG Yan(The First People's Hospital of Changzhou,Changzhou 213000,China)

机构地区：[1]常州市第一人民医院,江苏常州213000

出　　处：《临床医药实践》2023年第8期563-566,共4页Proceeding of Clinical Medicine

基　　金：常州市第十七批科技计划应用基础研究指导性基金资助项目(项目编号:CJ20209023);2022年常州市第十三批科技计划项目(项目编号:CM20223005)。

摘　　要：目的:研究载脂蛋白E(ApoE)基因多态性与脑梗死继发癫痫及血脂水平的关系。方法:将2020年7月—2022年3月常州市第一人民医院收治的78例脑梗死患者分为观察组39例(继发癫痫患者)和对照组39例(未继发癫痫患者),收集患者性别、年龄、基础疾病、肝肾功能指标等临床资料;检测两组患者ApoE基因型并比较ApoE基因型及等位基因的分布差异;比较两组不同ApoE基因型血脂指标的差异。结果:ApoE各基因型及等位基因在观察组及对照组的分布情况比较,差异无统计学意义(P>0.05);对照组ApoE各基因型间血脂指标含量比较,差异均无统计学意义(P>0.05);观察组ApoE基因E3型患者低密度脂蛋白胆固醇(LDL-C)及载脂蛋白B(ApoB)含量显著高于E2型,而高密度脂蛋白胆固醇(HDL-C)及载脂蛋白A1(ApoA1)含量显著低于E4型,差异均有统计学意义(P<0.05)。结论:脑梗死后是否继发癫痫可能与ApoE基因多态性无显著相关性,但临床需密切关注脑梗死继发癫痫患者部分血脂类指标,以便及时处理相关症状。Objective:To investigate the relationship between apolipoprotein E(ApoE)gene polymorphisms and epilepsy secondary to cerebral infarction,lipid levels in Han chinese population.Methods:All 78 patients who had cerebral infarction admitted to the first people's hospital of changzhou from July 2020 to March 2022 were collected,and 39 patients who had epilepsy secondary to cerebral infarction were grouped as the observation group,and another 39 patients without epilepsy secondary to cerebral infarction were grouped as the control group,and collected the general clinical data of patients such as gender,age,underlying diseases,liver and kidney function from the electronic medical record system.The ApoE genotype in the two groups were detected and the distribution of ApoE genotype and alleles were analyzed and compared between the two groups.The differences in blood lipid indexes of ApoE genotypes between the two groups were also compared.Results:There were no significant differences in the distribution of ApoE genotypes and alleles between the two groups(P>0.05).In patients who had cerebral infarction without secondary epilepsy,there were no significant statistical differences in the levels of blood lipid indexes among ApoE genotypes(P>0.05),but LDL-C and ApoB in the type E3 were significantly higher than those of type E2,and HDL-C and ApoA1 were significantly lower than those of type E4 in patients with epilepsy secondary to cerebral infarction(P<0.05).Conclusion:Whether secondary epilepsy occurs after cerebral infarction may not be significantly related to ApoE gene polymorphisms,it is necessary to pay close attention to the relevant blood lipid indexes in patients who had secondary epilepsy after cerebral infarction in order to deal with the relevant symptoms in time.

关 键 词：APOE基因多态性 脑梗死 继发癫痫 血脂 

分 类 号：R742.1[医药卫生—神经病学与精神病学]