喉癌患者细胞凋亡抑制蛋白1的表达情况及预后影响因素  

Expression of cell-inhibitor of apoptosis protein-1 in patients with laryngeal carcinoma and the influencing factors for prognosis

作　　者：刘婷 钱雅琴 宋若会[2] 朱玲[2] LIU Ting;QIAN Yaqin;SONG Ruohui;ZHU Ling(Department of Otolaryngology,the Eighth People′s Hospital of Hefei,Hefei 238000,Anhui,China;Department of Oncology,the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230000,Anhui,China)

机构地区：[1]合肥市第八人民医院耳鼻喉科,安徽省合肥市238000 [2]安徽中医药大学第一附属医院肿瘤科,安徽省合肥市230000

出　　处：《广西医学》2023年第10期1148-1152,共5页Guangxi Medical Journal

基　　金：安徽高校自然科学研究重点项目(KJ2017A283)。

摘　　要：目的探讨喉癌患者喉癌组织细胞凋亡抑制蛋白1(c-IAP1)的表达情况及影响患者预后的因素。方法回顾性分析60例喉癌患者的临床资料,采集患者术后喉癌组织与癌旁组织病理切片,采用免疫组织化学法测定c-IAP1的表达情况。比较喉癌患者喉癌组织与癌旁组织中c-IAP1的表达情况,以及不同预后患者喉癌组织中c-IAP1的表达情况。采用多因素COX回归模型分析影响喉癌患者预后的因素。结果喉癌组织中c-IAP1高表达率高于癌旁组织(P<0.05)。本组60例患者中,预后不良42例(70.00%),预后良好18例(30.00%),预后不良患者喉癌组织c-IAP1高表达率高于预后良好患者(P<0.05)。多因素COX回归分析结果显示,c-IAP1表达情况、组织学分级、肿瘤大小、淋巴结转移情况、临床分期是喉癌患者预后的影响因素(均P<0.05)。结论喉癌患者喉癌组织中c-IAP1阳性表达率升高,c-IAP1表达情况、组织学分级、肿瘤大小、淋巴结转移情况、临床分期是喉癌患者预后的影响因素。Objective To explore the expression of cell-inhibitor of apoptosis protein 1(c-IAP1)in laryngeal cancerous tissues of patients with laryngeal carcinoma,and the factors in affecting patients′prognosis.Methods The clinical data of 60 patients with laryngeal carcinoma were retrospectively analyzed.Pathological sections of postoperative laryngeal cancerous and paracancerous tissues of patients were collected,and c-IAP1 expression was measured by the immunohistochemistry.The expression of c-IAP1 in patients with laryngeal carcinoma were compared between laryngeal cancerous tissues and paracancerous tissues,and c-IAP1 expression in laryngeal cancerous tissues was also compared between patients with different prognoses.The multivariate COX regression model was used to analyze the factors in affecting laryngeal carcinoma patients′prognosis.Results The high expression rate of c-IAP1 in laryngeal cancerous tissues was higher than that in paracancerous tissues(P<0.05).There were 42(70.00%)patients with adverse prognosis,and 18(30.00%)patients with favourable prognosis in 60 patients of this group,and the high expression rate of c-IAP1 in laryngeal cancerous tissues was higher in patients with adverse prognosis than in patients with favourable prognosis(P<0.05).The results of multivariate COX regression analysis depicted that c-IAP1 expression,histological classification,tumor size,lymph node metastasis,and clinical stage were the influencing factors for prognosis of patients with laryngeal carcinoma(all P<0.05).Conclusion The positive expression rate of c-IAP1 is elevated in laryngeal cancerous tissues of patients with laryngeal carcinoma.The expression of c-IAP1,histological classification,tumor size,lymph node metastasis,clinical stage are the influencing factors for laryngeal carcinoma patients′prognosis.

关 键 词：喉癌 癌组织 癌旁组织 细胞凋亡抑制蛋白1 预后 预测价值 

分 类 号：R739.65[医药卫生—肿瘤]