胸腔镜肺段切除术治疗非小细胞肺癌对血清LDH及ProGRP指标的效果  

Effect of Thoracoscopic Segmental Resection for Non-small Cell Lung Cancer on Serum LDH and ProGRP Indicators

作　　者：熊家俊 朱学雨 陈乐 张世浩 夏少锋 XIONG Jiajun;ZHU Xueyu;CHEN Le;ZHANG Shihao;XIA Shaofeng(Department of Cardiothoracic Surgery,the First People's Hospital of Jiujiang,Jiujiang 332000,China)

机构地区：[1]九江市第一人民医院心胸外科,江西九江332000

出　　处：《中国医药指南》2023年第19期25-28,共4页Guide of China Medicine

摘　　要：目的分析探讨在非小细胞肺癌患者的治疗中使用胸腔镜肺段切除术对患者体内血清LDH和PreoGRP水平指标效果和影响。方法选择在2021年3月至2023年2月,来我院接受治疗的非小细胞肺癌患者120例作为本次研究对象,并按照随机数字表法的方式,分为研究组和对照组。对照组患者使用胸腔镜肺叶切除手术对患者进行治疗,研究组使用胸腔镜肺段切除术的方式给予患者治疗。比较两组患者治疗后的相关围手术期指标、肺功能指标、相关炎性因子水平、相关预后结果、相关血清肿瘤因子水平以及患者的总并发症发生率。结果两组治疗结束后,研究组患者的手术时间、术中出血量、住院时间、拔管时间以及淋巴结清扫的个数和引流量均优于对照组(P<0.05);研究组患者的FEV1、FVC、PEF的指标明显高于对照组(P<0.05);研究组患者的血沉、CRP、降钙素原、白细胞的水平指标明显优于对照组(P<0.05);研究组患者的局部复发指数以及区域性转移指数的结构明显少于对照组(P<0.05);研究组患者的LDH、ProGRP、NSE的水平指标明显低于对照组(P<0.05);研究组患者术后出现肺部感染、皮下气肿、肺漏气的人数明显少于对照组(P<0.05)。结论在对非小细胞肺癌患者进行治疗期间使用胸腔镜肺段切除术,能有效缩短患者的相关临床治疗时间,改善患者的肺功能,降低体内相关的炎症水平和血清肿瘤指标,减少患者手术出现并发症的风险和概率。Objective To analyze and explore the effectiveness and impact of thoracoscopic segmental resection in the treatment of non-small cell lung cancer patients on serum LDH and PreoGRP levels.Methods One hundred and twenty patients with non-small cell lung cancer who came to our hospital for treatment from March 2021 to February 2023 were selected as the study subjects,and were divided into a study group and a control group using a random number table method.The control group patient was treated with thoracoscopic lobectomy,and the study group treated the patient with thoracoscopic segmental resection.Compare the relevant perioperative indicators,lung function indicators,inflammatory factor levels,prognosis results,serum tumor factor levels,and overall complication rate of two groups of patients after treatment.Results After the treatment of both groups,the study group surgical time,intraoperative bleeding,hospital stay,extubation time,number of lymph node dissection,and drainage volume were better than the control group(P<0.05).The indicators of FEV1,FVC,and PEF in the study group were significantly higher than those in the control group(P<0.05).The levels of ESR,CRP,procalcitonin and leukocyte in the study group were significantly better than those in the control group(P<0.05).The structure of local recurrence index and regional metastasis index in the study group patients was significantly lower than that in the control group(P<0.05).The levels of LDH,ProGRP,and NSE in the study group were significantly lower than those in the control group(P<0.05).The number of postoperative pulmonary infections,subcutaneous emphysema,and pulmonary leakage in the study group was significantly lower than that in the control group(P<0.05).Conclusion During the treatment of non-small cell lung cancer patients,thoracoscopic segmental resection can effectively shorten the relevant clinical treatment time,improve lung function,reduce inflammation levels and serum tumor indicators in the body,and reduce the risk and probability of surgic

关 键 词：非小细胞肺癌 胸腔镜肺段切除术 血清LDH水平指标 血清PreoGRP水平指标 

分 类 号：R734.2[医药卫生—肿瘤]