国产纳米炭混悬液在恶性肿瘤前哨淋巴结活检中的应用进展  

Application progress of domestic carbon nanoparticles suspension in sentinel lymph node biopsy for malignant tumors

作　　者：王熠昕 曹蒙 王焱 Wang Yixin;Cao Meng;Wang Yan(Department of Dermatological Surgery,Hospital for Skin Diseases,Institute of Dermatology,Chinese Academy of Medical Science,Peking Union Medical College,Nanjing 210042,China;Department of Cosmetic Laser Surgery,Hospital for Skin Diseases,Institute of Dermatology,Chinese Academy of Medical Science,Peking Union Medical College,Nanjing 210042,China)

机构地区：[1]中国医学科学院北京协和医学院皮肤病医院皮肤外科,南京210042 [2]中国医学科学院北京协和医学院皮肤病医院激光科,南京210042

出　　处：《国际肿瘤学杂志》2023年第1期22-27,共6页Journal of International Oncology

基　　金：国家自然科学基金(81872216)。

摘　　要：前哨淋巴结(SLN)是原发肿瘤淋巴结转移必经的首站淋巴结,各类示踪剂是目前SLN领域的研究热点。国产纳米炭混悬液(CNP)作为第三代特异性淋巴示踪剂,具有良好的淋巴系统趋向性,能在短时间内对淋巴结进行染色且不进入血液循环,在各类恶性肿瘤中得到了广泛应用。虽然仍有不少因素会影响到CNP示踪的有效性,但与其余种类示踪剂相比具有安全高效、无放射性、操作简便等优势,有望成为识别恶性肿瘤SLN转移的有力手段。Sentinel lymph nodes(SLNs)are the first lymph nodes to undergo lymph node metastasis from primary tumors,and various tracers are currently being researched in the field of SLNs.Domestic carbon nanoparticles suspension(CNP)has a good lymphatic system tropism,can indeed stain lymph nodes in a short time without entering the blood circulation,and has been widely used in various malignant tumors as a third generation specific lymphatic tracer.Although there are still many factors that affect the effectiveness of CNP tracer,CNP has the advantages of safety,high efficiency,non-radioactivity and easy operation compared with other kinds of tracers,and is expected to be a powerful means to identify SLNs metastasis of malignant tumors.

关 键 词：肿瘤 淋巴结 纳米粒子 

分 类 号：R730.4[医药卫生—肿瘤]