化疗后骨髓抑制机制的研究进展  

Research progress on the mechanism of bone marrow suppression after chemotherapy

作　　者：孙琦 李文倩[2] 解友邦[2] 周厚法 Sun Qi;Li Wenqian;Xie Youbang;Zhou Houfa(Graduate School of Qinghai University,Xining 810016,China;Department of Hematology,Qinghai Provincial People's Hospital,Xining 810000,China)

机构地区：[1]青海大学研究生院,西宁810016 [2]青海省人民医院血液科,西宁810000

出　　处：《国际肿瘤学杂志》2023年第1期33-36,共4页Journal of International Oncology

基　　金：国家血液系统疾病临床医学研究中心转化研究课题(2021WWB04);青海省血液系统疾病临床研究中心项目(2021-SF-136)。

摘　　要：化疗作为肿瘤的有效治疗手段,在清除肿瘤细胞的同时,对机体增殖旺盛的细胞尤其是造血细胞也产生明显的杀伤作用,造成化疗后骨髓抑制,影响化疗药物治疗效果及治疗周期。因此,从造血微环境损伤及造血干细胞衰老两方面入手,探讨化疗后骨髓抑制机制,可为肿瘤化疗后骨髓抑制的干预及管理提供新思路及理论支持。As an effective treatment for cancer,chemotherapy not only removes tumor cells,but also produces obvious killing effects on proliferating cells,especially hematopoietic cells,resulting in bone marrow suppression after chemotherapy,and affecting the effects of chemotherapy drug treatment and treatment cycle.Therefore,starting from the aspects of hematopoietic microenvironment damage and hematopoietic stem cell aging,to explore the mechanism of myelosuppression after chemotherapy,which provides new ideas and theoretical support for the intervention and management of bone marrow suppression after cancer chemotherapy.

关 键 词：造血干细胞 细胞衰老 骨髓抑制 化疗 造血微环境 

分 类 号：R730.53[医药卫生—肿瘤]