Development of novel Gemini-cholesterol analogues for retinoid-related orphan receptors  

作　　者：Uxía Gómez-Bouzó Alioune Fall Judit Osz Yagamare Fall ORCID logo Natacha Rochel Hugo Santalla 

机构地区：[1]Departamento de Química Orgánica,Facultade de Química,University of Vigo,Campus Lagoas de Marcosende,36310 Vigo,Spain [2]Department of Integrative Structural Biology,IGBMC-CNRS UMR7104-Inserm U964,1,rue Laurent Fries,67400 Illkirch,France

出　　处：《Organic Chemistry Frontiers》2022年第6期1522-1530,共9页有机化学前沿（英文）

基　　金：supported financially by the Xunta de Galicia(ED431C2017/70).

摘　　要：Retinoic-acid-related Orphan Receptors (RORs) regulate the maintenance of the circadian rhythm and immune response among others and are involved in increasing numbers of pathologies including autoimmune diseases, cancer and neurological disorders leading to huge interest in the development of ROR ligands. Here, we describe the synthesis of six novel Gemini cholesterol analogues and the binding mode of one of them to RORγ.

关 键 词：ANALOGUES synthesis NUMBERS 

分 类 号：O62[理学—有机化学]