Construction of quaternary carbon centers by KOtBu-catalyzed α-homoallylic alkylation of lactams with 1,3-dienes  

作　　者：Shang Wang Yunfei Xiang Tiantian Chen Xiang Wu Dong Xing 

机构地区：[1]Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200062,China

出　　处：《Organic Chemistry Frontiers》2022年第6期1642-1648,共7页有机化学前沿（英文）

基　　金：support from the National Natural Science Foundation of China(21772043);the Shanghai Pujiang Program(No.19PJ1403000)is greatly acknowledged.

摘　　要：We report a KOtBu-catalyzed α-homoallylic alkylation of lactams with 1,3-dienes. With this transitionmetal-free and atom-economical protocol, a variety of α-homoallylic alkylated lactams bearingα-quaternary carbon centers were formed in a 2,1-addition manner with excellent regioselectivity. Acation–π interaction between the in situ-generated potassium enolate and the diene is proposed to play akey role in accelerating this transformation.

关 键 词：QUATERNARY CENTERS CATALYZED 

分 类 号：O62[理学—有机化学]