HFIP-mediated three-component imidization of electron-rich arenes with in situ formed spiroindolenines for facile construction of 2-arylspiroindolenines  

作　　者：Chunyan Ge Liang Wang Fangzhi Hu Zhanshuai Ding Xinyao Li Deshuai Xiao Jiayi Wang Shuai-Shuai Li 

机构地区：[1]College of Chemistry and Pharmaceutical Sciences,Qingdao Agricultural University,Qingdao 266109,China

出　　处：《Organic Chemistry Frontiers》2022年第6期1696-1702,共7页有机化学前沿（英文）

基　　金：We are grateful to the NSFC(21978144 and 21776148);the Support Plan on Science and Technology for Youth Innovation of Universities in Shandong Province(2019KJM002);The financial support from the Talents of High Level Scientific Research Foundation(6651118009,6631115015,and 6631110309);the Postgraduate Innovation Program(QNYCX20016);the Central Laboratory of Qingdao Agricultural University for NMR determination is also gratefully acknowledged.

摘　　要：The three-component reaction of o-aminobenzaldehydes with 5-hydroxyindole and electron-rich areneshas been achieved through HFIP-mediated cascade hydride transfer/dearomative cyclization/CDC-typeimidization at room temperature under air,providing a variety of 2-arylspiroindolenines carrying diversefunctional groups with moderate to good yields.The derivatizations of the products also were conductedto enhance the synthetic practicality of this protocol.

关 键 词：INDOLE FACILE BENZALDEHYDE 

分 类 号：O62[理学—有机化学]