基于数据挖掘探究古代多寐病中医用药规律  

Exploring the Rules of Traditional Chinese Drugs for Narcolepsy in Ancient Times Based on Data Mining

作　　者：梁博豪 刘媛[1] 周岳君[1] 温成平[1] 邱一吾 赵青青 王雪姗 LIANG Bohao;LIU Yuan;ZHOU Yuejun(Zhejiang Chinese Medical University,Hangzhou(310053),China)

机构地区：[1]浙江中医药大学,杭州310053

出　　处：《浙江中医药大学学报》2023年第5期532-539,共8页Journal of Zhejiang Chinese Medical University

基　　金：国家重点研发计划项目(2018YFC1705500)。

摘　　要：[目的]探索古代中医文献中治疗多寐病的用药规律,为临床治疗多寐病提供参考。[方法]从《中华医典》第5版里先秦到民国之间的中医古籍中共筛检出829首方剂,采用Excel 2016、SPSS 25.0、SPSS Modeler 18.0软件对药物进行频数分析、关联规则分析和聚类分析,研究多寐病用药规律,挖掘治疗多寐病的有效处方。[结果] 829首多寐病方剂共涉及477味中药,频数≥50的高频药物有32味,其中频数最高的3味药物是甘草、人参、茯苓。多寐方中以补虚药和解表药最多,合占41.92%;药味以甘、辛、苦最多,占88.45%;药性以温性最多,占43.37%;归经最多依次为脾、肺、胃、心,合占68.66%。关联规则分析发现23组药对,支持度最高的三组药对分别是甘草→陈皮、甘草→白术and人参、甘草→大枣。聚类分析发现6组聚类方。[结论]古人认为多寐病以脾虚湿盛为主要病机,以扶阳抑阴为主要治法,用药首重甘温补脾之品,甘温配辛药以化阳、合苦药以燥湿,遣方补而不滞,重视阴阳平衡与气机升降。[Objective]To explore the medication rules for the treatment of narcolepsy in ancient Chinese literature,and to provide reference for clinical treatment of narcolepsy.[Methods]A total of 829 prescriptions were screened in the ancient Chinese medicine books from the pre-Qin period to the Republic of China in the Chinese Medical Classic(Fifth Edition).Excel 2016,SPSS 25.0 and SPSS Modeler 18.0 software were used to perform frequency analysis,association rule analysis,and cluster analysis of drugs to study the medication rules of narcolepsy,excavate effective prescriptions for narcolepsy.[Results]A total of 477 traditional Chinese drugs were involved in 829 prescriptions for narcolepsy.There were 32 high-frequency drugs with a frequency of≥50.Among them,the three most frequently used drugs were Glycyrrhizae radix et rhizoma,Ginseng radix et rhizoma and Poria cocos.Among the narcolepsy recipes,the most common ones were tonic drugs and diaphoretic,accounting for 41.92%;sweet,acrid and bitter were the most flavored,accounting for 88.45%;most medicinal properties were warm,accounting for 43.37%;The most common meridians were spleen,lung,stomach and heart,accounting for 68.66%.Association rule analysis found 23 drug pairs,and the three drug pairs with the highest support were Glycyrrhizae radix et rhizoma→Citri reticulatae pericarpium,Glycyrrhizae radix et rhizoma→Atractylodis macrocephalae rhizoma and Ginseng radix et rhizoma,Glycyrrhizae radix et rhizoma→Ziziphus jujuba Mill.Cluster analysis found that there were 6 groups of clusters.[Conclusion]The ancients believed that the main pathogenesis of narcolepsy was the spleen deficiency and dampness excess,and the main treatment method was to nourish Yang and suppress Yin.The first priority was to use sweet and warm drugs to nourish the spleen.Sweet and warm drugs were combined with pungent drugs to resolve Yang and bitter drugs to remove dampness.The prescription was supplemented without stagnation,and the balance of Yin and Yang and the rise and fall of Qi were e

关 键 词：数据挖掘 多寐 中华医典 用药规律 关联规则 聚类分析 药对 嗜睡症 

分 类 号：R741[医药卫生—神经病学与精神病学]