炎症相关信号通路在帕金森病中的研究进展  

Research progress of inflammation-related signaling pathways in Parkinson's disease

作　　者：陈缤彬 税玉莲 石清明 任治琼 贾渊缘 白云 李佳桦 刘柯婷 肖莉[4] CHEN Bin-bin;SHUI Yu-lian;SHI Qing-ming;REN Zhi-qiong;JIA Yuan-yuan;BAI Yun;LI Jia-hua;LIU Keting;XIAO Li(Anesthesiology Major,Grade 2019,Chengdu Medical College,Chengdu Sichuan 610500,China;Anesthesiology Major,Grade 2020,Chengdu Medical College,Chengdu Sichuan 610500,China;Center of Disease Control and Prevention,Western Theater Command,Lanzhou Gansu 730020,China;Department of Neurology,Chengdu Seventh People's Hospital,Chengdu Sichuan 610200,China;Department of Human Anatomy/Development and Regeneration Key Laboratory of Sichuan Province,Chengdu Medical College,Chengdu Sichuan 610500,China)

机构地区：[1]成都医学院,四川成都610500 [2]西部战区疾病预防控制中心,甘肃兰州730020 [3]成都市第七人民医院神经内科,四川成都610200 [4]成都医学院人体解剖学教研室/发育与再生四川省重点实验室,四川成都610500

出　　处：《局解手术学杂志》2023年第8期729-733,共5页Journal of Regional Anatomy and Operative Surgery

基　　金：四川省大学生创新实验项目(202213705031,S202113705079,S201913705054);2022年成都市医学科研课题(2022307);成都医学院-成都市第七人民医院联合科研基金项目(2021LHJYPJ-07)。

摘　　要：帕金森病(PD)是一种常见的神经退行性疾病,病理表现主要为黑质区多巴胺神经元进行性丢失,纹状体多巴胺(DA)含量减少及α-突触核蛋白堆积,临床表现为静止性震颤、肌肉僵直、运动缓慢、姿势异常等。尽管PD的病因尚未明确,但来自人类样本和动物模型的大量证据表明炎症参与其发病或进展,提示炎症可能是PD发生发展的重要机制之一。本文就帕金森病相关炎症信号通路展开综述,以期为开发抗炎新药治疗PD提供参考。Parkinson´s disease(PD)is a common neurodegenerative disease.Its pathological manifestations are mainly the progressive loss of dopamine neurons in the substantia nigra,the decrease of dopamine(DA)content in the striatum and the accumulation ofα-synuclein.Its clinical manifestations are static tremor,muscle rigidity,bradykinesia,and abnormal posture.Although the etiology of PD is not yet clear,there is a large amount of evidence from human samples and animal models that inflammation is involved in its pathogenesis or progression,suggesting that inflammation may be one of the important mechanisms for the occurrence and development of PD.This article reviews the inflammation-related signaling pathways in Parkinson´s disease,in order to provide reference for the development of new antiinflammatory drugs for the treatment of PD.

关 键 词：帕金森病 炎症 信号通路 综述 

分 类 号：R742[医药卫生—神经病学与精神病学]