缺血性脑卒中后神经发生相关信号通路及药物研究进展  

Reasearch progress of signaling pathways and related therapies in neurogenesis after ischemic stroke

作　　者：陈彦熹 徐志栋[2] 孙芳玲 王文 CHEN Yanxi;XU Zhidong;SUN Fangling;WANG Wen(Experimental Animal Center,Xuanwu Hospital,Capital Medical University Beijing Municipal Geriatric Medical Research Center,Beijing 100053,China;School of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Hebei Province,Shijiazhuang 050018,China)

机构地区：[1]首都医科大学宣武医院北京市老年病医疗研究中心实验动物室,北京100053 [2]河北科技大学化学与制药工程学院,河北石家庄050018

出　　处：《中国医药导报》2023年第21期35-39,共5页China Medical Herald

基　　金：国家自然科学基金面上项目(82173795)。

摘　　要：缺血性脑卒中是一种严重降低人们生活质量的脑血管疾病,该病的有效治疗药物阿替普酶溶栓时间窗狭窄,限制了患者的应用。Wnt/β-catenin、Notch、PI3K/Akt、MAPK、Eph-ephrin通路在中枢神经系统发育中具有重要作用,参与细胞生长、迁移、黏附的过程。由于成年人神经细胞生长已经停止,重新激活这些通路可能为内源性再生修复脑损伤带来希望,寻找靶向这些通路参与神经发生的机制和药物将会有利于缺血性脑卒中康复,本文就上述通路参与神经发生的关键过程及药物开发作一综述。Ischemic stroke is a cerebrovascular disease that seriously reduces people’s quality of life.The effective therapeutic drug of this disease,Alteplase,has a narrow thrombolytic time window,which limits the application of patients.Wnt/β-catenin,Notch,PI3K/Akt,MAPK,and Eph-ephrin pathways play important roles in the development of central nervous system and are involved in cell growth,migration,and adhesion.Since adult nerve cells growth have been stopped,reactivation of these pathways may bring hope for endogenous regeneration and repair of brain injury.Finding mechanisms and drugs targeting these pathways involved in neurogenesis will be beneficial to stroke rehabilitation.This article reviews the key processes and drug development of these pathways involved in neurogenesis.

关 键 词：缺血性脑卒中 神经发生 干细胞 信号通路 治疗药物 

分 类 号：R743.3[医药卫生—神经病学与精神病学]