胶质母细胞瘤相关小胶质细胞研究现状  

Research status of glioblastoma-associated microglia

作　　者：费文静 王文保[2] 谢欢欢 闫婧[2] 杨觅[1,2] Fei Wenjing;Wang Wenbao;Xie Huanhuan;Yan Jing;Yang Mi(Comprehensive Cancer Centre of Nanjing Drum Tower Hospital,Clinical College of Nanjing Medical University,Nanjing 210008,China;Comprehensive Cancer Centre of Nanjing Drum Tower Hospital,Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China;Comprehensive Cancer Centre of Nanjing Drum Tower Hospital,Clinical College of Nanjing University of Chinese Medicine,Nanjing 210008,China)

机构地区：[1]南京医科大学鼓楼临床医学院肿瘤中心,南京210008 [2]南京大学医学院附属鼓楼医院肿瘤中心,南京210008 [3]南京中医药大学鼓楼临床医学院肿瘤中心,南京210008

出　　处：《国际肿瘤学杂志》2022年第7期420-424,共5页Journal of International Oncology

摘　　要：小胶质细胞不同于巨噬细胞,具有独特的起源和作用。在胶质母细胞瘤中,小胶质细胞在调节肿瘤免疫状态、促进肿瘤血管生成、破坏血脑屏障及降低治疗敏感性等方面发挥了重要作用。因而在胶质母细胞瘤的放疗、化疗、免疫治疗中联合针对小胶质细胞的疗法也已成为具有临床前景的治疗方式。Microglia differ from macrophages with unique origin and role.In glioblastoma,microglia plays an important role in regulating tumor immune status,promoting tumor angiogenesis,destroying the bloodbrain barrier,and reducing the sensitivity of treatment.Therefore,the combination of microglial therapy in the radiotherapy,chemotherapy and immunotherapy of glioblastoma has also become a clinically promising treatment.

关 键 词：脑肿瘤 免疫调节 

分 类 号：R739.4[医药卫生—肿瘤]