循环游离核酸在结直肠癌临床诊疗中的应用  

Application of circulating cell-free nucleic acid in clinical diagnosis and treatment of colorectal cancer

作　　者：高一钊 刘洋 刘秋龙 邢金良 Gao Yizhao;Liu Yang;Liu Qiulong;Xing Jinliang(College of Medical Technology,Shaanxi University of Chinese Medicine,Xianyang 712000,China;College of Basic Medicine,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]陕西中医药大学医学技术学院,咸阳712000 [2]空军军医大学基础医学院,西安710032

出　　处：《国际肿瘤学杂志》2022年第9期555-559,共5页Journal of International Oncology

基　　金：国家自然科学基金(81830070)。

摘　　要：结直肠癌(CRC)发病率逐年上升,早期诊断对改善患者预后意义重大。循环游离核酸(cfNA)具有无创、实时监测、克服肿瘤异质性等优势。对cfNA含量、突变、甲基化以及片段化模式等特征进行分析,为CRC的早期诊断、疗效监测、预后判断以及用药指导等方面提供了重要参考价值。但cfNA要实际应用于CRC的临床诊疗中还需解决检测技术未标准化、检测成本高、高诊断效能标志物的筛选以及多组合模型的构建等问题,这些挑战将为未来cfNA的研究提供新方向。The incidence of colorectal cancer(CRC)is increasing year by year,and early diagnosis is of great significance to improve the prognosis of patients.Circulating cell-free nucleic acid(cfNA)has the advantages of non-invasive,real-time monitoring,and overcoming tumor heterogeneity.The characteristics of cfNA content,mutation,methylation and fragmentation patterns provid important reference value for early diagnosis,curative effect monitoring,prognosis judgment and medication guidance of CRC.However,the practical application of cfNA in the clinical diagnosis and treatment of CRC still needs to solve the problems of unstandardized detection technology,high detection cost,screening of markers with high diagnostic efficacy,and construction of multi-combination models.These challenges will provide new directions for future cfNA research.

关 键 词：结直肠肿瘤 临床实验室技术 治疗学 游离核酸 

分 类 号：R735.34[医药卫生—肿瘤]