益肾活血解毒方联合揿针治疗肾虚血瘀型多发性骨髓瘤患者周围神经病变的临床效果  

Clinical effect of Yishen Huoxue Jiedu Decoction combined with press-needle on peripheral neuropathy in patients with multiple myeloma of kidney deficiency and blood stasis type

作　　者：高二超 李迎巧 庞红翠 周振环 王茂生 GAO Erchao;LI Yingqiao;PANG Hongcui;ZHOU Zhenhuan;WANG Maosheng(Department of Hematology,Langfang Traditional Chinese Medicine Hospital,Hebei Province,Langfang065000,China)

机构地区：[1]河北省廊坊市中医医院血液科,河北廊坊065000

出　　处：《中国医药导报》2023年第19期143-148,共6页China Medical Herald

基　　金：全国名老中医药传承工作室建设项目(国中医药人教函〔2022〕75号);全国中医临床优秀人才研修项目(国中医药人教函〔2022〕1号);河北省中医药管理局中医药类科研计划项目(2020440);河北省廊坊市科技支撑计划项目(2021013014)。

摘　　要：目的探讨益肾活血解毒方联合揿针治疗肾虚血瘀型多发性骨髓瘤患者周围神经病变的临床效果。方法选取2019年10月至2022年8月河北省廊坊市中医医院肾虚血瘀型多发性骨髓瘤周围神经病变患者共80例,按照随机数字表法将其分为对照组和研究组,每组40例。对照组给予西药甲钴胺、叶酸营养神经治疗,研究组在口服营养神经基础上采用益肾活血解毒方联合揿针治疗。两组均治疗2个疗程。比较治疗前后两组周围神经病变分级改善情况、免疫功能、生活质量[卡氏功能状态评分(KPS)、疼痛程度数字评估量表(NRS)、匹兹堡睡眠质量指数量表(PSQI)、汉密尔顿焦虑量表(HAMA)]、中医症状评分。结果治疗后,两组周围神经病变分级情况优于治疗前,且研究组优于对照组(P<0.05);治疗后研究组CD4+、CD4+/CD8+高于治疗前,且研究组高于对照组(P<0.05);研究组CD8+低于治疗前,且研究组低于对照组(P<0.05);治疗后,两组KPS评分高于治疗前,且研究组高于对照组(P<0.05),两组NRS、PSQI、HAMA评分均低于治疗前,且研究组低于对照组(P<0.05);治疗后,两组手足麻木、感觉障碍、肢体疼痛和遇寒加重积分均低于治疗前,且研究组低于对照组(P<0.05)。结论益肾活血解毒方联合揿针治疗肾虚血瘀型多发性骨髓瘤患者周围神经病变具有很好的临床效果,改善患者周围神经病变,调节免疫功能,改善睡眠质量及焦虑,提高患者生活质量。Objective To investigate the clinical effect of Yishen Huoxue Jiedu Decoction combined with press-needle on peripheral neuropathy in patients with multiple myeloma of kidney deficiency and blood stasis type.Methods A total of 80 peripheral neuropathy patients with multiple myeloma of kidney deficiency and blood stasis type in Langfang Traditional Chinese Medicine Hospital of Hebei Province from October 2019 to August 2022 were selected and divided into control group and study group according to random number table method,with 40 cases in each group.The control group was given the western medicine Mecobalamin and Folic acid nutritional nerve treatment,and the study group was treated with Yishen Huoxue Jiedu Decoction combined with press-needle on the basis of oral nutritional nerve treatment.Both groups were treated for two courses.The improvement of peripheral neuropathy grading,immune function,quality of life(Karnofsky performance status[KPS],pain degree numerical rating scale[NRS],Pittsburgh sleep quality index scale[PSQI],Hamilton anxiety scale[HAMA]),and traditional Chinese medicine symptom score of the two groups were compared before and after treatment.Results After treatment,the grade of peripheral neuropathy in the two groups was better than before treatment,and the study group was better than the control group(P<0.05).After treatment,CD4+and CD4+/CD8+in the study group were higher than before treatment,and those in the study group were higher than those in the control group(P<0.05).CD8+in the study group was lower than that before treatment,and that in the study group was lower than that in the control group(P<0.05).After treatment,the KPS score of the two groups was higher than before treatment,and that of the study group was higher than that of the control group(P<0.05).NRS,PSQI,and HAMA scores of the two groups were lower than before treatment,and those of the study group were lower than those of the control group(P<0.05).After treatment,the scores of hand and foot numbness,sensory disturbance,limb pa

关 键 词：揿针 多发性骨髓瘤 益肾活血解毒方 周围神经病变 

分 类 号：R73[医药卫生—肿瘤]