清胆和胃法治疗胆汁反流性胃炎临床疗效及安全性Meta分析  

Clinical Effect and Safety of the Method of Cleaning the Gallbladder and Harmonizingthe Stomach in the Treatment of Bile Reflux Gastritis:A Meta-analysis

作　　者：张博 张定梅[2] 熊文生[3] ZHANG Bo;ZHANG Dingmei;XIONG Wensheng

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]中山大学公共卫生学院,广东广州510080 [3]广州中医药大学第一附属医院脾胃科,广东广州510405

出　　处：《新中医》2023年第11期29-39,共11页New Chinese Medicine

摘　　要：目的:系统评价清胆和胃法治疗胆汁反流性胃炎(BRG)的临床疗效和安全性。方法:检索国内外数据库,收集自2013年1月至2022年12月正式发表的有关清胆和胃法方药对比常规西医治疗BRG的随机对照试验(RCT)。使用“Cochrane偏倚风险评估”工具对纳入研究进行质量评价,采用RevMan5.3软件对收集数据进行分析。结果:纳入的28项临床RCT包含总样本2 177例,其中观察组1 089例,对照组1 088例。分析发现,清胆和胃法在总有效率、中医证候积分、胃动素(MTL)、胃泌素(GAS)、胆汁反流情况、胃黏膜改善等方面疗效优于常规西医治疗;不良反应、复发率低于西医治疗。结论:清胆和胃法治疗BRG较单纯西医常规治疗效果更优,安全性更高,更不易复发。Objective:To systematically evaluate the clinical efficacy and safety of the method of cleaning the gallbladder and harmonizing the stomach in the treatment of bile reflux gastritis(BRG).Methods:To search domestic and foreign databases and collect randomized controlled trials(RCTs)on the treatment of BRG with the method of cleaning the gallbladder and harmonizing the stomach compared to conventional western medicine,which were officially published from January 2013 to December 2022.The"Cochrane Bias Risk Assessment"tool was used to evaluate the quality of the included study,and the collected data were analyzed using RevMan5.3 software.Results:The 28 clinical RCTs included a total of 2177 samples,including 1089 cases in the observation group and 1088 cases in the control group.The analysis found that the method of cleaning the gallbladder and harmonizing the stomach was superior to conventional western medicine in terms of total effective rate,traditional Chinese medicine(TCM)syndrome score,motilin(MTL),gastrin(GAS),bile reflux,and improvement of gastric mucosa.Adverse reactions and recurrence rates were lower than those of western medicine treatment.Conclusion:The method of cleaning the gallbladder and harmonizing the stomach for treating BRG is more effective,safer,and less recurrence than conventional treatment with western medicine alone.

关 键 词：胆汁反流性胃炎 清胆和胃法 META分析 疗效 安全性 

分 类 号：R573.34[医药卫生—消化系统]