血塞通注射液联合丁苯酞胶囊对急性脑梗死患者血清炎症因子、血流动力学及神经功能的影响  

Effects of Xuesaitong Injection Combined with Butylphthalide Capsules on Serum Inflammatory Factors,Hemodynamics,and Neurological Function in Patients with Acute Cerebral Infarction

作　　者：李松林[1] 屈振楠 段鹏辉 蒋令修[1] LI Songlin;QU Zhennan;DUAN Penghui;JIANG Lingxiu

机构地区：[1]河南大学第一附属医院,河南开封475000

出　　处：《新中医》2023年第11期81-85,共5页New Chinese Medicine

摘　　要：目的:观察血塞通注射液联合丁苯酞胶囊对急性脑梗死患者血清炎症因子、血流动力学及神经功能的影响。方法:将100例急性脑梗死患者按随机数字表法分为2组各50例。对照组给予丁苯酞胶囊治疗,研究组在对照组基础上给予血塞通注射液治疗。比较2组治疗前后基质金属蛋白酶-9(MMP-9)、S-100B蛋白、神经元特异性烯醇化酶(NSE)、可溶性白细胞介素-2受体(sIL-2R)、白细胞介素-18(IL-18)、血管内皮生长因子(VEGF)、大脑中动脉搏动指数(PI)、平均血流速度(Vm)、阻力指数(RI)水平及美国国立卫生研究院卒中量表(NIHSS)、脑卒中专门化生存质量量表(SS-QOL)评分,并比较2组临床疗效。结果:治疗前,2组sIL-2R、IL-18、VEGF、S-100B蛋白、NSE、MMP-9水平比较,差异无统计学意义(P>0.05);治疗后,2组VEGF水平升高(P<0.05),且研究组高于对照组(P<0.05),2组sIL-2R、IL-18、S-100B蛋白、NSE、MMP-9水平降低(P<0.05),且研究组低于对照组(P<0.05)。治疗前,2组大脑PI、Vm、RI水平比较,差异无统计学意义(P>0.05);治疗后,2组大脑Vm水平升高(P<0.05),且研究组高于对照组(P<0.05),2组PI、RI水平降低(P<0.05),且研究组低于对照组(P<0.05)。治疗前,2组NIHSS、SS-QOL评分比较,差异无统计学意义(P>0.05);治疗后,2组SS-QOL评分升高(P<0.05),且研究组高于对照组(P<0.05),2组NIHSS评分降低(P<0.05),且研究组低于对照组(P<0.05)。研究组治疗总有效率96.00%,高于对照组80.00%(P<0.05)。结论:血塞通注射液联合丁苯酞胶囊治疗急性脑梗死患者,可抑制炎症,改善血流动力学及神经功能,提高临床疗效及生活质量。Objective:To observe the effect of Xuesaitong Injection combined with Butylphthalide Capsules on serum inflammatory factors,hemodynamics,and neurological function in patients with acute cerebral infarction.Methods:A total of 100 cases of patients with acute cerebral infarction were selected as research objects and divided into two groups according to the random number table method,with 50 cases in each group.The control group was treated with Butylphthalide Capsules,and the study group was additionally treated with Xuesaitong Injection based on the treatment of the control group.Before and after treatment,the levels of matrix metalloproteinase-9(MMP-9),S-100B protein,neuron-specific enolase(NSE),soluble interleukin-2 receptor(sIL-2R),interleukin-18(IL-18),vascular endothelial growth factor(VEGF),the pulsatility index(PI),mean blood velocity(Vm),and resistance index(RI)of middle cerebral artery,and the scores of National Institutes of Health Stroke Scale(NIHSS)and Stroke-specific Quality of Life(SS-QOL)were compared between the two groups.The clinical effects in the two groups were compared.Results:Before treatment,there was no significant difference being found in the comparison of the levels of sIL-2R,IL-18,VEGF,S-100B protein,NSE,and MMP-9 between the two groups(P>0.05).After treatment,VEGF levels in the two groups were increased(P<0.05),and VEGF level in the study group was higher than that in the control group;the levels of sIL-2R,IL-18,S-100B protein,NSE,and MMP-9 in the study group were decreased(P<0.05),and the above levels in the study group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of PI,Vm and RI in brain between the two groups(P>0.05).After treatment,the Vm levels in the two groups were increased(P<0.05),and the Vm level in the study group was higher than that in the control group(P<0.05),the levels of PI and RI in the two groups were decreased(P<0.05),and the levels in the study group were lower t

关 键 词：急性脑梗死 血塞通注射液 丁苯酞胶囊 炎症因子 血流动力学 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]