扶正解毒汤联合调强适形放疗治疗乳腺癌术后临床研究  

Clinical Study on Fuzheng Jiedu Decoction Combined with Intensity Modulated and Conformal Radiation Therapy for Post-operative Breast Cancer

作　　者：张晓 金月珍 陈寅 ZHANG Xiao;JIN Yuezhen;CHEN Yin

机构地区：[1]浙江金华广福肿瘤医院放疗科,浙江金华321000 [2]金华康复医院,浙江金华321000

出　　处：《新中医》2023年第11期173-177,共5页New Chinese Medicine

摘　　要：目的:观察扶正解毒汤联合调强适形放疗治疗乳腺癌术后的临床疗效。方法:选取80例乳腺癌术后患者为研究对象,按随机数字表法分为对照组与观察组各40例。对照组予以常规调强适形放疗,观察组在对照组基础上给予扶正解毒汤联合治疗。比较2组药物不良反应,比较2组治疗前后免疫功能及生活质量。结果:观察组药物不良反应总发生率17.5%,低于对照组55.0%(P<0.05)。治疗前,2组红细胞计数、白细胞计数、淋巴细胞计数、单核细胞计数水平比较,差异无统计学意义(P>0.05);治疗后,2组上述指标水平均降低(P<0.05),但观察组高于对照组(P<0.05)。治疗前,2组血清免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)水平比较,差异无统计学意义(P>0.05);治疗后,2组IgG、IgA、IgM水平均降低(P<0.05),但观察组高于对照组(P<0.05)。治疗前,2组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05);治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)降低(P<0.05),CD8^(+)升高(P<0.05),但观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05),CD8^(+)低于对照组(P<0.05)。治疗前,2组乳腺癌专用生存质量量表(FACT-B 4.0)各项评分及总分比较,差异无统计学意义(P>0.05);治疗后,2组FACT-B 4.0各项评分及总分均升高(P<0.05),且观察组高于对照组(P<0.05)。结论:扶正解毒汤联合调强适形放疗治疗乳腺癌术后,可有效降低术后药物不良反应,减轻放疗所致免疫损伤,提高术后生活质量。Objective:To observe the clinical effect of Fuzheng Jiedu Decoction combined with intensity modulated and conformal radiation therapy for post-operative breast cancer.Methods:A total of 80 cases of patients with post-operative breast cancer were selected as the study subjects,and divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was treated with routine intensity modulated and conformal radiation therapy,and the observation group was additionally treated with Fuzheng Jiedu Decoction based on the treatment of the control group.The adverse reactions of medication were compared between the two groups.Before and after treatment,the immune function and quality of life were compared between the two groups.Results:The total incidence of adverse reactions of medication was 17.5%in the observation group,lower than that of 55.0%in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of red blood cell count,white blood cell count,lymphocyte count,and monocyte count between the two groups(P>0.05);after treatment,the above levels in the two groups were decreased(P<0.05),and the levels in the observation group were higher than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of immunoglobulin G(IgG),immunoglobulin A(IgA),and immunoglobulin M(IgM)between the two groups(P>0.05);after treatment,the levels of IgG,IgA and IgM in the two groups were decreased(P<0.05),and the levels in the observation group were higher than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)between the two groups(P>0.05);after treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were decreased(P<0.05),and CD8^(+)was increased(P<0.05);the levels of CD3^(+),CD4^(+)and CD4^

关 键 词：乳腺癌术后 扶正解毒汤 调强适形放疗 免疫功能 生活质量 

分 类 号：R737.9[医药卫生—肿瘤]