Stability of within host HTLV-I/HIV-1 co-infection in the presence of macrophages  

作　　者：A.M.Elaiw N.H.Alshamrani E.Dahy A.A.Abdellatif 

机构地区：[1]Department of Mathematics Faculty of Science,King Abdulaziz University P.0.Box 80203,Jeddah 21589,Saudi Arabia [2]Department of Mathematics Faculty of Science,Al-Azhar University Assiut Branch,Assiut,Egypt [3]Department of Mathematics Faculty of Science,University of Jeddah P.O.Bor 80327,Jeddah 21589,Saudi Arabia

出　　处：《International Journal of Biomathematics》2023年第1期129-156,共28页生物数学学报（英文版）

基　　金：supported by the Deanship of Scientific Research(DSR);King Abdulaziz University,Jeddah,under grant no.(D-83-130-1443).

摘　　要：The main target of both human immunodeficiency virus type 1(HIV-1)and human Tlymphotropic virus type I(HTLV-I)is the CD4+T cell which is considered the key player in the immune system.Moreover,HIV-1 has another target that is the macrophages.The present paper aims to formulate and develop a mathematical model to analyze the interaction of two viruses,HIV-1 and HTLV-I with the immune system.We determine a bounded domain for the concentrations of the model's compartments.We discuss the dynamical behavior of the model and analyze the existence and stability of the system's steady states.The global asymptotic stability of all steady states is proven by utilizing the Lyapunov method.We also demonstrate the dynamical behavior of the system numerically.The significant impact of macrophages on the HTLV-I/HIV-1 co-infection dynamics is discussed.Our developed model will contribute to the understanding of HTLV-I/HIV-1 co-infection dynamics and help to choose different treatment strategies against HIV-1 and HTLV-I.

关 键 词：Viral co-infection CD4+T cells MACROPHAGES Lyapunov function global stability 

分 类 号：Q-332[生物学]