FTO及其在肿瘤中作用的研究进展  

Research progress on fat mass and obesity-associated protein and its role in tumors

作　　者：尹峰 喻辰唏 许文娇 潘永瀚 杨博文 陈思羚 罗文舸 吴志浩 YIN Feng;YU Chenxi;XU Wenjiao;PAN Yonghan;YANG Bowen;CHEN Siling;LUO Wenge;WU Zhihao(School of Clinical Medicine,Wannan Medical College,Wuhu 241002,China;Research Laboratory of Tumor Microenvironment,Wannan Medical College,Wuhu 241002,China;School of Medicine Imaging,Wannan Medical College,Wuhu 241002,China;School of Basic Medicine,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]皖南医学院临床医学院,安徽芜湖241002 [2]皖南医学院肿瘤微环境实验室,安徽芜湖241002 [3]皖南医学院医学影像学,安徽芜湖241002 [4]皖南医学院基础医学院,安徽芜湖241002

出　　处：《沈阳医学院学报》2023年第4期409-414,共6页Journal of Shenyang Medical College

基　　金：国家自然科学基金(No.81872371);分子肿瘤学国家重点实验室开放项目计划(No.SKL-KF-2019-11);安徽省自然科学基金项目(No.1708085MH203);国家级大学生创新创业训练计划(No.202110368032)。

摘　　要：肥胖蛋白(fat mass and obesity-associated protein,FTO)是一种RNA去甲基化酶,其与α-酮戊二酸加氧酶如AlkB同源家族(ALKBH)蛋白具有序列同源性,在m6A修饰方面发挥重要作用,可以调节RNA代谢的许多过程,包括降解和翻译等。越来越多的研究表明,FTO参与调控神经发生、多巴胺信号传导和食欲调节、脂肪发生、致癌和病毒感染等生物学过程。本文主要对FTO的结构与功能、在肿瘤中的作用机制,及其抑制剂进行综述。In the process of m6A regulation,FTO protein is responsible for demethylation.A major molecular function of fat mass and obesity-associated protein(FTO),which has sequence homology to alpha-ketoglutarate oxygenase enzymes such as the AlkB homolog family(ALKBH)proteins,is RNA demethylation.FTO plays an important role in m6A modification and can regulate many aspects of RNA metabolism,including degradation and translation.An increasing number of studies show that FTO is involved in the regulation of many cellular and biological processes,including neurogenesis,dopamine signaling and appetite regulation,adipogenesis,oncogenesis,and viral infection.This paper reviews the structure and function of FTO,its roles in tumors,and its inhibitors.

关 键 词：m6A 肥胖蛋白 肿瘤 抑制剂 

分 类 号：R730.2[医药卫生—肿瘤]