中药四性研究进展及方法回顾  

Four Properties of Chinese Herbal Medicine:A Review

作　　者：林林 李丽[1] 赵鹏程 刘斌 颜岚 段乃凡 李晓纳 吕诚[1] LIN Lin;LI Li;ZHAO Pengcheng;LIU Bin;YAN Lan;DUAN Naifan;LI Xiaona;LYU Cheng(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Life Sciences,Northwestern Polytechnical University,Xi'an 710072,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]西北工业大学生命学院,西安710072

出　　处：《中国实验方剂学杂志》2023年第15期267-272,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202005);中国中医科学院中研究员中央级公益性科研院所基本科研业务费专项(ZZ11-056)。

摘　　要：中药四性具有数千年的历史,是我国中药临床应用重要理论指导之一。然而,近年来少有针对中药四性研究方法和技术的综述。因此,该文通过筛选既往中药四性研究文章,总结中药四性研究进展和技术,明确各项技术特点、优势及适用对象,以期对未来四性深入研究提供参考。检索中国知网、万方、维普、PubMed、Cochrane library及EMbase数据库,筛选中药四性研究相关文献,提取文献中涉及的四性研究进展、研究对象和研究技术并进行归类、总结。目前中药四性研究技术主要包括文献数据研究、网络药理学、生物热力学、细胞学、蛋白质组学、代谢组学6类,研究层级可以划分为微层级、小层级、中层级、大层级。每项实验研究采用的研究对象不同,主要是单味中药、中药单体、靶点、菌群、细胞及小鼠和大鼠。不同研究技术从不同维度阐释了中药四性,从总体上表明中药四性存在的物质基础。在未来研究进程中,阐释中药四性可以首先定位研究层级,再依据研究层级选择相应研究技术、确定研究指标,得出研究结论,这将有助于中医药研究人员有效开展研究设计并完整实施中药四性研究相关实验。The four properties of Chinese herbal medicine have a history of several thousand years and are one of the important theoretical guides for the clinical application of Chinese herbal medicine.However,there have been few reviews of research methods and techniques for the four properties of Chinese herbal medicine in recent years.Therefore,this article summarized the advances and techniques for the four properties of Chinese herbal medicine by screening relevant literature on the four properties of Chinese herbal medicine and clarifying the characteristics,advantages,and applicable objects of each technique,in order to provide references for in-depth research on the four properties in the future.Chinese databases such as China national knowledge infrastructure(CNKI),Wanfang data,and VIP,as well as international databases including PubMed,Cochrane Library,and EMbase were searched for relevant literature on the four properties of Chinese herbal medicine.The advances,research objects,and research techniques involved in the literature were extracted,classified,and summarized.Currently,the research techniques for the four properties of Chinese herbal medicine mainly include six categories,i.e.,literature data research,network pharmacology,biothermodynamics,cell biology,proteomics,and metabolomics.The research hierarchy can be divided into micro-level,small-level,medium-level,and macro-level.The research objects used in each experimental study are different,mainly single Chinese herbal medicine,Chinese herbal monomers,targets,microbial communities,cells,mice,and rats.Different research techniques explain the four properties of Chinese herbal medicine from different dimensions,which overall indicate the material basis of the four properties of Chinese herbal medicine.In future research,the interpretation of the four properties of Chinese herbal medicine can be first located at the research hierarchy,then corresponding research techniques can be selected according to the research hierarchy,and research indicators can be de

关 键 词：中药四性 研究进展 研究方法 研究技术 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R289R33