同期植入颈动脉支架对急诊血管内治疗颈动脉串联病变患者近期预后的影响  

Effect of Concurrent Carotid Stent Implantation on Short-Term Prognosis of Patients with Carotid Artery Tandem Disease Treated in Emergency Endovascular Treatment

作　　者：田永娟 左娜 郭延莉 TIAN Yong-juan;ZUO Na;GUO Yan-li(Department of Neurosurgery,Nanyang Central Hospital,Nanyang,Henan,473000,China)

机构地区：[1]南阳市中心医院神经外科,河南南阳473000

出　　处：《中国血液流变学杂志》2023年第1期96-99,共4页Chinese Journal of Hemorheology

摘　　要：目的探讨同期植入颈动脉支架对急诊血管内治疗颈动脉串联病变患者近期预后的影响,为行急诊血管内治疗的颈动脉串联病变患者良好的预后提供有效的科学依据。方法将2019年2月-2020年2月收治的123例行急诊血管内治疗的颈动脉串联病变患者采用回顾性分析的方法分为两组,对照组61例给予急诊血管内治疗,观察组62例在对照组的基础上予以植入颈动脉支架治疗,观察两组患者血流动力学、美国国立卫生研究院卒中量表(NIHSS)评分、炎性因子水平、术后90d最终事件(再次住院、心血管死亡)的发生情况。结果治疗后,两组左侧椎动脉(LVA)、右侧椎动脉(RVA)、基底动脉(BA)血流速度均上升,观察组高于对照组(P<0.05);两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、白细胞介素-4(IL-4)均下降,且观察组低于对照组(P<0.05);观察组最终事件发生率(3.23%)低于对照组(6.56%),但差异无统计学意义(P>0.05);治疗后,两组NIHSS评分均降低,观察组较对照组低(P<0.05)。结论同期植入颈动脉支架对急诊血管内治疗颈动脉串联病变可减轻患者体内的氧化应激反应,改善神经功能,减轻炎症水平,且不增加再次住院及心血管死亡的发生率。Objective To investigate the effect of simultaneous carotid artery stent implantation on the shortterm prognosis of patients with carotid artery tandem disease undergoing emergency endovascular treatment,and to provide effective scientific basis for the good prognosis of patients with carotid artery tandem disease undergoing emergency endovascular treatment.Methods 123 patients with carotid artery tandem disease who received emergency endovascular treatment from February 2019 to February 2020 were divided into two groups by retrospective analysis.61 patients in the control group received emergency endovascular treatment,and 62 patients in the observation group received carotid artery stenting on the basis of the control group.Oxidative stress indicators,National Institutes of Health Stroke Scale(NIHSS)score,inflammatory factor levels,and the incidence of final events(re-hospitalization and cardiovascular death)90 days after surgery in 2 groups were observed.Results After treatment,the blood flow velocity of left vertebral artery(LVA),right vertebral artery(RVA)and basilar artery(BA)in both groups increased,and the observation group was higher than the control group(P<0.05).Tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP)and interleukin-4(IL-4)were decreased in both groups,and observation group was lower than control group(P<0.05).The final event incidence in the observation group(3.23%)was lower than that in the control group(6.56%),and there was no statistical significance(P>0.05).After treatment,NIHSS score was decreased in both groups,and the observation group was lower than the control group(P<o.05).Conclusion Concurrent carotid stent implantation for emergency intravascular treatment of carotid artery tandem disease can reduce oxidative stress response,improve nerve function,reduce inflammation level,and do not increase the incidence of rehospitalization and cardiovascular death.

关 键 词：颈动脉支架 急诊血管内治疗 颈动脉串联病变 氧化应激 

分 类 号：R743.3[医药卫生—神经病学与精神病学]