软组织恶性肿瘤超声造影增强模式参数与临床预后相关性研究  

Correlation between Enhancement Pattern and Parameters of Contrast- enhanced Ultrasound and Clinical Prognosis in Patients with Soft Tissue Malignancies

作　　者：杨爽[1] 段丽红 孙雅 朱宇航 胡艳[1] YANG Shuang;DUAN Lihong;SUN Ya;ZHU Yuhang;HU Yan(Department of Ultrasound,Zhongshan Hospital Affiliated to Dalian University,Dalian,Liaoning 116001,China)

机构地区：[1]大连大学附属中山医院超声科,辽宁大连116001

出　　处：《临床误诊误治》2023年第6期32-38,共7页Clinical Misdiagnosis & Mistherapy

基　　金：大连市卫生健康委员会项目(1711098);大连市医学科学研究计划项目(1711101)。

摘　　要：目的 探究软组织恶性肿瘤患者超声造影(CEUS)增强模式参数与临床预后相关性。方法 选取2021年1月—2022年1月收治的软组织恶性肿瘤58例作为研究组,另选同期软组织良性肿瘤58例作为对照组。比较2组CEUS增强模式参数,并比较研究组不同临床特征患者CEUS增强模式参数,分析CEUS增强模式参数与软组织恶性肿瘤患者临床特征的相关性。比较研究组术后1年复发与未复发患者术前CEUS增强模式参数,分析CEUS增强模式参数与软组织恶性肿瘤术后复发的相关性,评估CEUS增强模式参数预测软组织恶性肿瘤术后复发的价值。结果 研究组造影剂到达时间(AT)、达峰时间(TTP)均较对照组短,峰值强度(DPI)、上升支斜率(A)均高于对照组(P<0.05)。研究组不同肿瘤最大径、病灶数目、美国肌肉骨骼肿瘤协会(MSTS)分期、法国国家抗癌中心联合会(FNCLCC)分级患者AT、TTP、DPI、A比较差异有统计学意义(P<0.01);AT、TTP与软组织恶性肿瘤肿瘤最大径、病灶数目、MSTS分期、FNCLCC分级呈负相关,DPI、A与肿瘤最大径、病灶数目、MSTS分期、FNCLCC分级呈正相关(P<0.05)。复发患者术前AT、TTP低于未复发患者,DPI、A高于未复发患者(P<0.05,P<0.01);AT、TTP与软组织恶性肿瘤术后复发呈负相关(r=-0.426、-0.510,P<0.01),DPI、A与软组织恶性肿瘤术后复发呈正相关(r=0.524、0.557,P<0.01);AT、TTP、DPI、A联合预测术后复发的曲线下面积(AUC)大于各参数单独预测的AUC(P<0.01)。结论 CEUS增强模式可用于软组织肿瘤早期诊断及病情评估,可为临床早期预测预后、制订针对性治疗方案提供参考依据,以降低术后复发风险。Objective To explore the correlation between enhancement pattern and parameters of contrast-enhanced ultrasound(CEUS)and clinical prognosis in patients with soft tissue malignancies.Methods Fifty-eight patients with soft tissue malignancies admitted from January 2021 to January 2022 were selected as the research group,and 58 patients with benign soft tissue tumors during the same period were selected as the control group.The enhancement pattern and parameters of CEUS of the two groups were compared,and the enhancement pattern and parameters of CEUS of patients with different clinical characteristics in the research group were compared.The correlation between enhancement pattern and parameters of CEUS and clinical characteristics of patients with soft tissue malignancies was analyzed.Preoperative enhancement pattern and parameters of CEUS were compared between patients with and without recurrence at 1 year after surgery in the research group,and the correlation between enhancement pattern and parameters of CEUS and postoperative recurrence of soft tissue malignancies was analyzed.The value of enhancement pattern and parameters of CEUS in predicting postoperative recurrence of soft tissue malignancies was evaluated.Results The arrival time(AT)and time to peak(TTP)of contrast agent in the research group were shorter than those in the control group,while the derived peak intensity(DPI)and slope of ascending time(A)of contrast agent in the research group were higher than those in the control group(P<0.05).There were significant differences in AT,TTP,PI and A among patients with different tumor size,number of lesions,American Musculoskeletal Tumor Society(MSTS)stage and the French National Federation of Cancer Centers(FNCLCC)grade(P<0.01).AT and TTP were negatively correlated with maximum tumor diameter,number of lesions,MSTS stage and FNCLCC grade,while DPI and A were positively correlated with maximum tumor diameter,number of lesions,MSTS stage and FNCLCC grade(P<0.05).Before operation,AT and TTP of patients with rec

关 键 词：软组织恶性肿瘤 超声造影 造影剂到达时间 达峰时间 峰值强度 上升支斜率 复发 预后 

分 类 号：R730.41[医药卫生—肿瘤]