中药纳米技术靶向治疗脑部疾病研究进展  

Research progress of targeted treatment of brain diseases with Chinese medicine nanotechnology

作　　者：范容晖 阳志强 李勃深 张宇轩 李晓琳 李茂星 FAN Ronghui;YANG Zhiqiang;LI Boshen;ZHANG Yuxuan;LI Xiaolin;LI Maoxing(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Clinical Pharmacy,the 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army,Lanzhou 730050;Gansu Plateau Pharmaceutical Technology Center,Lanzhou 730050;College of Pharmacy,Lanzhou University,Lanzhou 730000;Institute of Chemical Technology,Northwest Minzu University,Lanzhou 730030;Institute of Radiation Medicine Sciences,Academy of Military Medical,Academy of Military Sciences,Beijing 100850)

机构地区：[1]甘肃中医药大学药学院,兰州730000 [2]中国人民解放军联勤保障部队第九四〇医院临床药学科,兰州730050 [3]甘肃省高原药学行业技术中心,兰州730050 [4]兰州大学药学院,兰州730000 [5]西北民族大学化工学院,兰州730030 [6]军事科学院军事医学研究院辐射医学研究所,北京100850

出　　处：《中国比较医学杂志》2023年第6期128-140,共13页Chinese Journal of Comparative Medicine

基　　金：后勤科研项目(CLB21J036);拔尖培育项目(2021yxky001);青年培育项目(2021yxky060);应急医学科研项目(20yjky018);甘肃省卫生行业科研计划项目(GSWSKY2020-41);甘肃省中医药管理局科研项目(GZK-2019-36)。

摘　　要：脑部疾病在临床上较为常见,危害着人类的生命健康。血脑屏障的存在能够防止血液中的有害物质进入大脑,维持大脑的稳态环境,但同时也阻止药物进入大脑发挥药效。纳米技术具有组织靶向的优点,中药活性物质治疗脑部疾病具有良好的效果,纳米技术与中药活性物质结合治疗脑部疾病可增强靶向性。Brain diseases are common in clinical practice.The blood-brain barrier prevents harmful substances from entering the brain and maintains homeostasis,but it also prevents drugs from entering the brain to exert effects.Nanotechnology has the advantage of tissue targeting.Active substances in Chinese traditional medicine have a good treatment effect on brain diseases.The combination of nanotechnology and active substances in Chinese traditional medicine for the treatment of brain diseases enhances targeting.

关 键 词：血脑屏障 药物递送 纳米粒 中药制剂 靶向技术 

分 类 号：R-33[医药卫生]