Padua与IMPEDE评估量表在新诊断多发性骨髓瘤患者静脉血栓栓塞症预测中的比较研究:单中心数据  

Comparison of the predictive value of Padua and the IMPEDE assessment scores for venous thromboembolism in patients with newly diagnosed multiple myeloma:A single institution experience

作　　者：房立娟[1] 姚晓东[1] 陆敏秋[1] 褚彬[1] 石磊[1] 高珊[1] 项秋晴 王宇彤 刘晰 丁月华 陈远 王梦真 赵鑫 胡惟恺 孙恺 鲍立[1] Fang Lijuan;Yao Xiaodong;Lu Minqiu;Chu Bin;Shi Lei;Gao Shan;Xiang Qiuqing;Wang Yutong;Liu Xi;Ding Yuehua;Chen Yuan;Wang Mengzhen;Zhao Xin;Hu Weikai;Sun Kai;Bao Li(Department of Hematology,Beijing Jishuitan Hospital,Beijing 100096,China)

机构地区：[1]北京积水潭医院,北京100096

出　　处：《中华血液学杂志》2023年第5期395-400,共6页Chinese Journal of Hematology

摘　　要：目的比较两种血栓风险评估量表(Padua评分与IMPEDE评分)对中国新诊断多发性骨髓瘤(NDMM)患者6个月内发生静脉血栓栓塞症(VTE)的预测效能。方法回顾性分析2014年4月至2022年2月北京积水潭医院NDMM住院患者的临床资料。采用Padua评分与IMPEDE评分对患者进行VTE的风险评估量化,依据受试者工作特征曲线(ROC)的曲线下面积(AUC)比较两种血栓风险评估量表对NDMM确诊后6个月内发生VTE的预测价值,并计算其灵敏度、特异度、准确率及约登指数。结果本研究共纳入NDMM患者421例,VTE发生率为14.73%。Padua评分预测VTE的AUC为0.591(95%CI 0.515~0.666)。IMPEDE评分预测VTE的AUC为0.722(95%CI 0.648~0.796)。Padua评分预测VTE的灵敏度为100%,特异度为0%,准确率为14.7%,约登指数为0%。IMPEDE评分预测VTE的灵敏度为79.0%,特异度为44.0%,准确率为49.2%,约登指数为23.0%。结论IMPEDE评分适用于NDMM患者6个月内发生VTE的预测。Objective To compare the predictive efficacy of the two thrombosis risk assessment scores(Padua and IMPEDE scores)in venous thromboembolism(VTE)within 6 months in patients with newly diagnosed multiple myeloma(NDMM)in China.Methods This study reviewed the clinical data of 421 patients with NDMM hospitalized in Beijing Jishuitan Hospital from April 2014 to February 2022.The sensitivity,specificity,accuracy,and Youden index of the two scores were calculated to quantify the thrombus risk assessment of VTE by the Padua and IMPEDE scores.The receiver operating characteristics curves of the two evaluation scores were drawn.Results The incidence of VTE was 14.73%.The sensitivity,specificity,accuracy,and Youden index of the Padua score were 100%,0%,14.7%,and 0%and that of the IMPEDE score was 79%,44%,49.2%,and 23%,respectively.The areas under the curve of Padua and IMPEDE risk assessment scores were 0.591 and 0.722,respectively.Conclusion IMPEDE score is suitable for predicting VTE within 6 months in patients with NDMM.

关 键 词：静脉血栓栓塞 多发性骨髓瘤 Padua评分 IMPEDE评分 

分 类 号：R733.3[医药卫生—肿瘤]