女性双相躁狂共病代谢障碍的早期筛查及相关性研究  

Early screening and correlation study of bipolor mania and comorbid metabolic disorder in women

作　　者：李峥 王淑贤 阎琳 宋延艳 邵玉单 王体宾 亓晶颖 张雪丽 翟永利 孙前明 付慧鹏 李猛 孔德荣 LI Zheng;WANG Shu-xian;YAN Lin;SONG Yan-yan;SHAO Yu-dan;WANG Ti-bin;QI Jing-ying;ZHANG Xue-li;ZHAI Yong-li;SUN Qian-ming;FU Hui-peng;LI Meng;Kong De-rong(Zhengzhou Eighth Peoples Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市第八人民医院心理障碍科,郑州450000

出　　处：《医药论坛杂志》2023年第10期57-60,共4页Journal of Medical Forum

基　　金：河南省医学科技攻关计划项目(2018020866)。

摘　　要：目的 探讨女性双相躁狂患者可能存在的代谢异常指标,并探讨其与临床症状的相关性,为临床预防、治疗提供依据。方法 选取2018年12月—2020年8月在郑州市第八人民医院治疗的126例女性双相躁狂患者为研究组,125例健康女性对照组,收集两组的年龄、家族史、婚姻状况、月经情况,测量腰围、收缩压、舒张压指标。抽取受试者(研究组在接受治疗前)的空腹静脉血,检测血糖、血脂、尿酸等指标。对研究组进行杨氏躁狂量表(YMRS)、汉密尔顿17项抑郁量表(HAMD-17)评估。使用Pearson相关性分析,探讨代谢异常指标与临床症状的相关性。结果 研究组的家族史阳性率、BMI指数明显高于对照组(χ^(2)=27.825,P<0.001)(χ^(2)=4.323,P<0.001);研究组在腰围、收缩压(SBP)、舒张压(DBP)、尿酸(UA)代谢相关指标上高出正常对照组,结果分别为(t=4.519,P<0.001)(t=5.839,P<0.001)(t=5.809,P<0.001)(t=5.059,P<0.001),研究组在高密度脂蛋白(HDL-C)指标上则低于正常对照组(t=-10.075,P<0.001);研究组的血尿酸(UA)水平与YMRS量表中的心境障碍及活动精力增加呈正相关(r=0.205,P=0.021)(r=0.189,P=0.034)。结论 女性双相躁狂患者在治疗前即可能存在腰围增加、收缩压(SBP)、舒张压(DBP)、UA水平升高情况,且UA值与心境障碍及活动精力增加正相关,为女性双相躁狂的早期干预提供临床依据。Objective To investigate the metabolic abnormality indicators of bipolar mania in women,and to explore their correlation between metabolic abnormality indicators and clinical symptoms.Methods A total of 126 female patients with bipolar mania treated in the Eighth Peoples Hospital of Zhengzhou from December 2018 to August 2020 were enrolled as study group,125 healthy women were contral group.The age,family history,marital status and menstrual status of the patients were collected,and the waist circumference,systolic blood pressure and diastolic blood pressure indexes were measured.The fasting venous blood of the subjects(the study group before receiving treatment)was taken to detect blood glucose,blood lipids,uric acid and other indicators.Study groups were assessed on the Youngs Mania Scale(YMRS)and Hamiltons 17-Item Depression Scale(HAMD-17)Pearson correlation analysis was used to explore their correlation between metabolic indicators and clinical symptoms.ResultsThe family history positivity rate and BMI index in the study group were significantly higher than those of the control group(χ^(2)=27.825,P<0.001),(χ^(2)=4.323,P<0.001).The results were higher than those of the normal control group in terms of waist circumference,systolic blood pressure(SBP),diastolic blood pressure(DBP),and uric acid(UA)metabolism in the study group,and the results were(t=4.519,P<0.001),(t=5.839,P<0.001),(t=5.809,P<0.001)(t=5.059,P<0.001).The HDL-C in the study group was lower than that of the control group(t=-10.075,P<0.001).The blood uric acid(UA)level in the study group was positively correlated with mood disorders and increased activity energy in the YMRS scale(r=0.205,P=0.021),(r=0.189,P=0.034).Conclusion Female patients with bipolar mania may have increased waist circumference,systolic blood pressure(SBP),diastolic blood pressure(DBP),and UA levels may increase before treatment.UA values are positively correlated with mood disorders and increased activity energy,which provides a clinical basis for early intervention of female

关 键 词：女性 双相障碍躁狂发作 代谢综合征 相关性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]