Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood  

作　　者：Ran Li Jing Zou Dongling Pei Ting Pan Bing Yang Xianzhi Liu Yan Chen Fangfang Zhou Long Zhang 

机构地区：[1]Hematology Department,The Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen,518000,China [2]MOE Key Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network,Life Sciences Institute,Zhejiang University,Hangzhou,310058,China [3]Department of Neurosurgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450001,China [4]Institute of Human Virology,Zhongshan School of Medicine,Sun Yat-sen University,510080,Guangzhou,China [5]Institutes of Biology and Medical Sciences,Soochow University,Suzhou,215123,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第6期2471-2474,共4页信号转导与靶向治疗（英文）

基　　金：supported by the National Key R&D Program of China(2021YFA1101000,2022YFA1105200);the Chinese National Natural Science Funds(31870902,32070907,31871405,U20A20393,81760041);the National Science Fund for Distinguished Young Scholars(32125016,31925013);Zhejiang Natural Science Fund(LD19C070001);the Jiangsu National Science Foundation(19KJA550003).

摘　　要：Dear Editor,Overwhelming evidence suggests that age itself is a prominent risk factor for COVID-19 morbidity and mortality.^(1,2)However,the molecular basis of aging’s effect on SARS-CoV-2 susceptibility and COVID-19 severity in adults is still not fully understood.Thus,we hypothesized that aging-related cellular landscape alterations influence clinical manifestations,which is critical for determining likely intervention targets to slow the transmission of COVID-19 and reduce severe symptoms.

关 键 词：alterations MORTALITY AGING 

分 类 号：R563.1[医药卫生—呼吸系统]