Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development  

作　　者：Qi Xu Miaomiao Xie Xiaoxuan Liu Heng Heng Han Wang Chen Yang Edward Wai-Chi Chan Rong Zhang Guan Yang Sheng Chen 

机构地区：[1]Department of Infectious Diseases and Public Health,Jockey Club College of Veterinary Medicine and Life Sciences,City University of Hong Kong,Kowloon,Hong Kong,China [2]State Key Lab of Chemical Biology and Drug Discovery and the Department of Food Science and Nutrition,The Hong Kong Polytechnic University,Hom Hung,Kowloon,Hong Kong,China [3]Department of Clinical Laboratory,Second Affiliated Hospital of Zhejiang University,School of Medicine,Zhejiang,Hangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第6期2489-2492,共4页信号转导与靶向治疗（英文）

基　　金：funded by the Theme-Based Research Scheme(T11-104/22-R);the Research Impact Fund(R5011-18F)from the Research Grant Council of the Government of China HongKong SAR.

摘　　要：Dear Editor,Klebsiella pneumoniae(Kp)has become the most important bacterial pathogen causing high mortality rates in clinical patients due to the continuous evolution to several important variants such as carbapenem-resistant(CR-Kp),hypervirulent(hvKp)and both CR and hv K.pneumoniae(CR-hvKp).The high mortality caused by clinical hvKp is attributed to the non-response to antibiotic treatment.

关 键 词：MORTALITY CLINICAL attributed 

分 类 号：R563.1[医药卫生—呼吸系统]