Macrophages in immunoregulation and therapeutics  

作　　者：Shanze Chen Abdullah F.U.H.Saeed Quan Liu Qiong Jiang Haizhao Xu Gary Guishan Xiao Lang Rao Yanhong Duo 

机构地区：[1]Department of Respiratory Diseases and Critic Care Unit,Shenzhen Institute of Respiratory Disease,Shenzhen Key Laboratory of Respiratory Disease,Shenzhen People’s Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China [2]Department of Cancer Biology,Beckman Research Institute of City of Hope National Medical Center,Los Angeles,CA,91010,USA [3]Department of Laboratory Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital),Shenzhen University,Shenzhen,518052,China [4]Department of Respiratory,The First Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China [5]State Key Laboratory of Fine Chemicals,Department of Pharmaceutical Sciences,School of Chemical Engineering,Dalian University of Technology,Dalian,China [6]Institute of Biomedical Health Technology and Engineering,Shenzhen Bay Laboratory,Shenzhen,518132,China [7]Department of Microbiology,Tumor and Cell Biology(MTC),Karolinska Institutet,Stockholm,Sweden

出　　处：《Signal Transduction and Targeted Therapy》2023年第6期I0002-I0002,2821-2854,共35页信号转导与靶向治疗（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos:81803183,82272779,82003036,82273236);National Key R&D Program of China(2022YFF0710800,2022YFF0710802);Natural Science Foundation of Sichuan province,China(No.2019YFS0230);Science and Technology Innovation Commission of Shenzhen(Nos:JCYJ20220530141608020,JCYJ20220530141609021);Natural Science Foundation of Guangdong province,China(Nos:2214050008970,2019A1515012079);Guangdong Basic and Applied Basic Research Foundation(Nos.2023A1515030182);Science and Technology Innovation Commission of Shenzhen(No.JCYJ20220530141608020)BioRender was used to create the figures.

摘　　要：Macrophages exist in various tissues,several body cavities,and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers.Macrophages possess binary M1/M2 macrophage polarization settings,which perform a central role in an array of immune tasks via intrinsic signal cascades and,therefore,must be precisely regulated.Many crucial questions about macrophage signaling and immune modulation are yet to be uncovered.In addition,the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their biology.Moreover,they are an integral part of the tumor microenvironment,playing a part in the regulation of a wide variety of processes including angiogenesis,extracellular matrix transformation,cancer cell proliferation,metastasis,immunosuppression,and resistance to chemotherapeutic and checkpoint blockade immunotherapies.Herein,we discuss immune regulation in macrophage polarization and signaling,mechanical stresses and modulation,metabolic signaling pathways,mitochondrial and transcriptional,and epigenetic regulation.Furthermore,we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage functions.Moreover,we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis.Lastly,we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases.

关 键 词：BECOMING POLARIZATION MACROPHAGES 

分 类 号：R614[医药卫生—麻醉学]