Comparing T-and B-cell responses to COVID-19 vaccines across varied immune backgrounds  

作　　者：Zhen Cui Wenxin Luo Ruihong Chen Yalun Li Zhoufeng Wang Yong Liu Shuo Liu LeiLei Feng Zijing Jia Ruixin Cheng Jun Tang Weijin Huang Yanjun Zhang Huawen Liu Xiangxi Wang Weimin Li 

机构地区：[1]CAS Key Laboratory of Infection and Immunity,National Laboratory of Macromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing,100101,China [2]Department of Respiratory and Critical Care Medicine,Institute of Respiratory Health,Precision Medicine Center,Precision Medicine Key Laboratory of Sichuan Province,Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu,610041,China [3]Precision Medicine Center,Precision Medicine Key Laboratory of Sichuan Province,Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu,610041,China [4]Department of Neurology,Chongqing University Three Gorges Hospital,Chongqing University,Chongqing,China [5]Division of HIV/AIDS and Sex-transmitted Virus Vaccines,Institute for Biological Product Control,National Institutes for Food and Drug Control(NIFDC),No.31 Huatuo Street,Daxing District,Beijing,102629,China [6]Department of Microbiology,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,China [7]Department of Oncology,Chongqing University Three Gorges Hospital,Chongqing University,Chongqing,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第6期3029-3038,共10页信号转导与靶向治疗（英文）

基　　金：supported by National Natural Science Foundation of China(92159302 to W.M.L.);the Fundamental Research Funds for the Central Universities(SCU2022D025 to W.M.L.);Science and Technology Foundation of Sichuan Province,China(2022NSFSC0842 to W.X.L.,2020YFS0572 to L.Y.L.);Ministry of Science and Technology of China(EKPG21-09 and CPL-1233);supported by Ten Thousand Talent Program and the NSFS Innovative Research Group(No.81921005).

摘　　要：The emergence of adapted variants of the SARS-CoV-2 virus has led to a surge in breakthrough infections worldwide.A recent analysis of immune responses in people who received inactivated vaccines has revealed that individuals with no prior infection have limited resistance to Omicron and its sub-lineages,while those with previous infections exhibit a significant amount of neutralizing antibodies and memory B cells.However,specific T-cell responses remain largely unaffected by the mutations,indicating that T-cell-mediated cellular immunity can still provide protection.Moreover,the administration of a third dose of vaccine has resulted in a marked increase in the spectrum and duration of neutralizing antibodies and memory B cells in vivo,which has enhanced resistance to emerging variants such as BA.2.75 and BA.2.12.1.These results highlight the need to consider booster immunization for previously infected individuals and the development of novel vaccination strategies.The rapid spread of adapted variants of the SARS-CoV-2 virus presents a significant challenge to global health.The findings from this study underscore the importance of tailoring vaccination strategies based on individual immune backgrounds and the potential need for booster shots to combat emerging variants.Continued research and development are crucial to discovering new immunization strategies that will effectively protect public health against the evolving virus.

关 键 词：vaccines IMMUNITY adapted 

分 类 号：R563.1[医药卫生—呼吸系统]