Carascynol A,a hybrid of caryophyllane-type terpenoid and a C6 unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron  

作　　者：Ya-Li Hu Xing-Ren Li Gang Xu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,and Yunnan Key Laboratory of Natural Medicinal Chemistry,Kunming 650201,Yunnan,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2022年第1期595-599,共5页应用天然产物（英文）

基　　金：supported by the NSFC-Joint Foundation of Yunnan Province (Grant No.U1902213);the Second Tibetan Plateau Scientific Expedition and Research (STEP)program (Grant No.2019QZKK0502-0303);Natural Science Foundation of Yunnan (Grant No.2019FA003);CAS Interdisciplinary Innovation Team of CAS“Light of West China”Program;the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (Grant No.E0230211Z1).

摘　　要：Carascynol A,an unprecedented 4/9/8 ring system hybrid with a peroxide bridge,was characterized from Hyperi-cum ascyron.The architecture contains a caryophyllane-type moiety and a C_(6) unit derived from polyprenylated acylphloroglucinols.Its structure and absolute configuration were determined by comprehensive spectroscopic and X-ray diffraction data.Biologically,compound 1 inhibited cell proliferation in LoVo,SW480,and HCT116 cell lines(IC_(50)=12.30-24.57μM).

关 键 词：Hypericum ascyron Caryophyllane Polyprenylated acylphloroglucinols CYTOTOXICITY Colon cancer 

分 类 号：O62[理学—有机化学]