^(18)F-PSMA-1007 PET/CT应用不同诊断标准对前列腺癌诊断效能的比较  

Comparison of the diagnostic efficacy of ^(18)F-PSMA-1007 PET/CT using different diagnostic criteria for prostate cancer

作　　者：陈丹丹 楼云龙[1] 宋丽 CHEN Dandan;LOU Yunlong;SONG Li(Department of Nuclear Medicine,Meizhou People's Hospital,Guangdong Meizhou 514013,China)

机构地区：[1]梅州市人民医院核医学科,广东梅州514013

出　　处：《现代肿瘤医学》2023年第15期2895-2899,共5页Journal of Modern Oncology

基　　金：广东省梅州市人民医院培育项目(编号:PY-C2020018)。

摘　　要：目的:探索18 F-PSMA-1007 PET/CT用不同诊断标准对前列腺良恶性病变的鉴别价值,并比较其诊断效能的差异。方法:回顾性分析102例临床高度怀疑为前列腺癌并行18 F-PSMA-1007 PET/CT的图像及临床资料,分别应用miPSMA评分、半定量分析法及PSMA-RADS评分对前列腺癌进行盲法诊断,以病理结果为金标准,得出对前列腺癌病灶的诊断效能,并利用MedCalc软件对ROC曲线下面积(AUC)进行比较。结果:102例患者中,57例为前列腺腺泡癌,其余45例为良性病变,包括1例前列腺炎性脓肿、3例前列腺增生伴炎症、38例前列腺增生改变及3例良性前列腺组织。miPSMA评分法、半定量分析法和PSMA-RADS评分对前列腺癌病灶诊断的灵敏度及特异性分别为70.2%(40/57)和88.9%(40/45)、73.7%(42/57)和95.6%(43/45)及78.9%(45/57)和46.7%(21/45),3种诊断标准对前列腺良恶性病变的鉴别差异均具有统计学意义(P值均<0.001),但3种诊断标准的AUC均无统计学差异(P值均>0.05)。结论:miPSMA评分法、半定量分析法和PSMA-RADS评分对前列腺良恶性病变的鉴别诊断均具有一定的价值,对前列腺癌的诊断效能无明显差异,3种标准对前列腺癌的诊断灵敏度均较高,但PSMA-RADS评分的特异性差。Objective:To explore the differential value of 18 F-PSMA-1007 PET/CT diagnostic criteria in benign and malignant prostate lesions,and to compare the difference in diagnostic efficacy.Methods:Retrospective analysis was performed on 102 cases of prostate cancer with high clinical suspicion and 18 F-PSMA-1007 PET/CT images and clinical data.miPSMA score,semi-quantitative analysis and PSMA-RADS score were used for blind diagnosis of prostate cancer,and pathological results were used as the gold standard.The diagnostic efficacy of prostate cancer foci was obtained,and area under ROC curve(AUC)was compared by MedCalc software.Results:In the 102 patients,there were 57 cases of prostate acinar carcinoma,the other 45 cases of benign lesions,including 1 case of prostatic abscess,3 cases of prostatic hyperplasia with inflammation,38 cases of prostatic hyperplasia changes and 3 cases of benign prostatic tissue.The sensitivity and specificity of miPSMA score,semi-quantitative analysis and PSMA-RADS score for diagnosis of prostate cancer lesions were 70.2%(40/57)and 88.9%(40/45),73.7%(42/57)and 95.6%(43/45),78.9%(45/57)and 46.7%(21/45),the three diagnostic criteria had statistical significance in the differentiation of benign and malignant prostate lesions(P<0.001).But there was no significant difference in the AUC of the three diagnostic criteria(all P values>0.05).Conclusion:miPSMA score,semi-quantitative analysis and PSMA-RADS score are of certain value in the differential diagnosis of benign and malignant prostate lesions,but there is no significant difference in the diagnostic efficacy of prostate cancer.The sensitivity of the three criteria is high,but the specificity of PSMA-RADS score is poor.

关 键 词：前列腺肿瘤 miPSMA评分 半定量分析 PSMA-RADS评分 正电子发射断层显像术 X线计算机体层摄影术 诊断 

分 类 号：R737.25[医药卫生—肿瘤]