TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System  

作　　者：Junzhuang Chang Cui Chen Wei Li Nashat Abumaria 

机构地区：[1]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Department of Laboratory Animal Science,Institutes of Brain Science,Fudan University,Shanghai,200032,China

出　　处：《Neuroscience Bulletin》2023年第6期989-993,共5页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(31970942 and 81573408);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);the ZJ Lab,and Shanghai Center for Brain Science and Brain-Inspired Technology.

摘　　要：Dear Editor,The ion channel transient receptor potential melastatin-like 7(TRPM7)has a serine-threonineα-kinase domain(M7CK)on its intracellular C-terminal[1,2].In cell lines,M7CK is cleaved and translocated to the nucleus to regulate a variety of cellular processes including cell proliferation and survival[3].In neuroblastoma cells.

关 键 词：RAC1 SSH2 NEUROBLASTOMA 

分 类 号：R338[医药卫生—人体生理学]