芬太尼联合异丙酚对非小细胞肺癌患者术中BPC、凝血指标以及ERI、EDI指数的影响  

Influence of fentanyl combined with propofol on BPC,coagulation index,ERI and EDI index in patients with non-small cell lung cancer during operation

作　　者：张晶[1] 程南[1] 王志云[1] 郑卫国[1] 沈迎雁 黄培[1] ZHANG Jing;CHENG Nan;WANG Zhi-yun;ZHENG Wei-guo;SHEN Ying-yan;HUANG Pei(Zhejiang Medical and Health Group Quzhou Hospital(Zhejiang Quhua Hospital),Quzhou,Zhejiang 324004,China)

机构地区：[1]浙江省医疗健康集团衢州医院(浙江衢化医院),浙江衢州324004

出　　处：《中国卫生检验杂志》2023年第13期1585-1587,1596,共4页Chinese Journal of Health Laboratory Technology

基　　金：衢州市科技计划项目(2018ASA90018)。

摘　　要：目的研究芬太尼联合异丙酚在非小细胞肺癌(NCLC)手术中对血小板(BPC)、凝血指标以及血液流变学指数(ERI、EDI)的影响。方法收纳本院2017年3月—2022年6月148例NCLC患者,分为2个组,一组为对照组,以异丙酚诱导麻醉,另一组为实验组,以芬太尼和异丙酚诱导麻醉,比较2组手术前后BPC、凝血指标以及ERI和EDI。结果手术前,2组PLT,MPV和PDW比较,差异均无统计学意义,手术进行30 min及手术后,2组PLT均增加,MPV、PDW降低(P<0.05);与对照组相比,实验组手术进行30 min以及术后PLT均降低,MPV、PDW增加(P<0.05);手术前后,2组的APTT、PT、TT、FIB比较,差异均无统计学意义(P>0.05);手术进行30 min及手术后,2组FIB增加,且实验组低于对照组;手术前,2组的红细胞ERI、EDI比较,差异均无统计学意义(P>0.05);手术进行30 min以及术后,2组的EDI均上升,ERI均降低(P<0.05);与对照组相比,实验组EDI明显较低,ERI则与之相反(P<0.05)。结论芬太尼联合异丙酚在NCLC手术中,对患者BPC,凝血指标以及ERI、EDI有更好的改观,更适合临床推广。Objective This paper aims to discuss the influence of fentanyl combined with propofol on BPC,coagulation index,ERI and EDI index in patients with non-small cell lung cancer during operation(NCLC).Methods A total of 148 patients with NCLC from March 2017 to June 2022 were enrolled and divided into two groups.One group was anesthetized with propofol(control group)and the other group was anesthetized with fentanyl and propofol(experimental group).BPC,coagulation index,ERI and EDI were compared between the two groups before and after surgery.Results Before surgery,the differences of PLT,MPV and PDW were not statistically significant between the two groups.30 min during surgery and after surgery,PLT increased and MPV and PDW decreased in both groups(P<0.05).Compared with the control group,PLT decreased and MPV and PDW increased in the experimental group at 30 min after operation(P<0.05).Before and after operation,there was no statistical significance on the differences in APTT,PT,TT and FIB between the two groups(P>0.05).At 30 min and after operation,FIB increased in both groups,and the experimental group was lower than the control group.Before operation,there was no statistical significance on the differences in erythrocyte ERI and EDI between the two groups(P>0.05).30 min during operation and after operation,EDI increased and ERI decreased in both groups(P<0.05).Compared with the control group,EDI was lower in the experimental group,but ERI was the opposite(P<0.05).Conclusion Fentanyl combined with propofol used in non-small cell carcinoma surgery has less impact on patients'BPC,coagulation indicators,ERI and EDI,which is suitable for clinical promotion.

关 键 词：芬太尼 异丙酚 非小细胞肺癌 血小板 凝血指标 血液流变学 

分 类 号：R734.2[医药卫生—肿瘤]