Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance  

作　　者：Ya-Nan Shi Jin-Zhu Su Juan Wang Jiang-Qiao Geng 

机构地区：[1]Department of Otolaryngology,Sanya Women and Children's Hospital,Sanya,572000,China [2]Department of Otolaryngology,Hebei Children’s Hospital,Shijiazhuang,050031,China

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第7期306-314,共9页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To evaluate the effect of myricetin on ovalbumin(OVA)-induced allergic rhinitis in mice.Methods:Mice were sensitized and challenged using OVA(5%,500 mL)intraperitoneally and intranasally,respectively,on an alternative day for 14 days,followed by administration of myricetin(50,100,and 200 mg/kg)till day 21.Nasal symptoms,biochemical parameters,protein expressions,and histopathology were observed.Results:OVA-induced increased nasal symptoms including rubbing,sneezing,and discharge were significantly reduced by myricetin(100and 200 mg/kg)(P<0.05).Myricetin also protected against histamine challenge and attenuated elevated serum immunoglobulin E(IgE;total and OVA-specific),total IgG1,andβ-hexosaminidase levels,as well as leukotriene C4 and interleukins levels in nasal lavage fluid(P<0.05).Western blot analysis showed that myricetin significantly upregulated the protein expression of T-box expressed in T cells,while downregulating the protein expression of GATA binding protein 3,NF-κB,and IκB-α(P<0.05).Additionally,OVA-induced histopathological abberations in the nasal mucosa was markedly ameliorated by myricetin treatment(P<0.05).Conclusions:Myricetin exerts anti-allergic effects against OVAinduced allergic rhinitis via regulating Th1/Th2 balance.

关 键 词：Allergic rhinitis GATA3 INTERLEUKINS MYRICETIN MONTELUKAST Ovalbumin Th1/Th2 balance 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]