滇重楼多糖对小鼠胃肠动力的影响  

Effect of Paris polyphylla Polysaccharide on Gastrointestinal Motility in Mice

作　　者：沙爱龙 熊彬冰 李媛媛 张尚红 王韵钦 任盈盈 梁婷 SHA Ailong;XIONG Binbing;LI Yuanyuan;ZHANG Shanghong;WANG Yunqin;REN Yingying;LIANG Ting(Chongqing Three Gorges UniversitySchool of Teacher Education,Chongqing 404120,China;b.Chongqing Three Gorges University School of biology and food engineering,Chongqing 404120,China)

机构地区：[1]重庆三峡学院教师教育学院,重庆404120 [2]重庆三峡学院重庆三峡学院生物与食品工程学院,重庆404120

出　　处：《牡丹江师范学院学报（自然科学版）》2023年第3期53-57,共5页Journal of Mudanjiang Normal University：Natural Sciences Edition

基　　金：国家自然科学基金项目(31360635);重庆市教育委员会科学技术研究项目(KJQN201901235,KJQN202001226,KJQN202101247);重庆三峡学院人才引进科研启动金项目(20190002)。

摘　　要：通过比较正常小鼠与滇重楼多糖组小鼠胃排空率、小肠推进率、十二指肠收缩活动的差异,研究滇重楼多糖对小鼠胃肠动力的影响.实验结果表明,低剂量滇重楼多糖极显著促进小鼠胃排空率(P<0.01),中剂量极显著抑制小鼠胃排空率而促进其小肠推进率(P<0.01),高剂量极显著延缓小鼠胃排空率和小肠推进率(P<0.01).离体实验结果表明,滇重楼多糖低、中剂量组兴奋十二指肠收缩幅度,而高剂量组极显著抑制十二指肠收缩幅度(P<0.01).滇重楼多糖对小鼠胃肠动力具双向调节效应,且最适浓度位于中、高剂量间.By comparing the gastric emptying rate,intestinal motility and duodenum contractile activity between normal mice and Paris polyphylla Polysaccharides-treated mice,study the effect of Paris polyphylla Polysaccharide on gastrointestinal motility in mice.The results showed that the Paris polyphylla Polysaccharide in the low-dose group could significantly promote gastric emptying in mice(P<0.01),the medium-dose Paris polyphylla Polysaccharide could significantly delay gastric emptying while promote gastric emptying(P<0.01),and in the high-dose Paris polyphylla Polysaccharide gastric emptying and intestinal motility were delayed in mice(P<0.01).Ex-vivo study showed Paris polyphylla Polysaccharide in the low,medium-dose groups induced duodenum contractile action,while Paris polyphylla Polysaccharide in the high-dose groups induced significantly relexation(P<0.01).Paris polyphylla Polysaccharide directionlly regulated the gastrointestinal motility,and the optimal concentration was between medium and high dose.

关 键 词：滇重楼多糖 离体肠 在体 胃肠动力 

分 类 号：TS202.3[轻工技术与工程—食品科学]