静电纺丝材料在功能性牙周组织再生中的应用与展望  

Application and prospect of electrospinning in functional periodontal tissue regeneration

作　　者：李璐[1] 徐艳[1] Li Lu;Xu Yan(Department of Periodontology,The Affiliated Stomatological Hospital of Nanjing Medical University&Jiangsu Province Key Laboratory of Oral Diseases&Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing 210029,China)

机构地区：[1]南京医科大学附属口腔医院牙周病科、江苏省口腔疾病研究重点实验室、江苏省口腔转化医学工程研究中心,南京210029

出　　处：《中华口腔医学杂志》2023年第7期636-641,共6页Chinese Journal of Stomatology

基　　金：国家自然科学基金(82170962,82201072,82211530117)。

摘　　要：牙周炎情况下局部组织微生态失衡可造成大量菌斑生物膜堆积,从而导致牙周组织破坏与附着丧失,并使牙周再生性愈合尤为困难。为突破牙周炎的临床治疗困境,近年来新型生物材料辅助的牙周组织再生治疗是研究的热点内容,其中具有良好生物相容性的静电纺丝材料备受关注。本文从牙周临床问题出发,提出并明确功能性牙周组织再生的重要性;并基于既往研究中静电纺丝材料在牙周组织再生领域的应用,分析了其促进功能性牙周组织再生的效果;同时探讨了静电纺丝材料实现牙周组织修复的内在机制并提出未来的研究方向,以期为牙周炎的临床治疗提供新策略。In the case of periodontitis,local microecological imbalance can cause a large number of plaque biofilm accumulations,leading to the destruction of periodontal tissue and attachment loss,which makes it particularly difficult for the periodontal regenerative healing.In order to overcome the clinical treatment dilemma of periodontitis,periodontal tissue regeneration therapy assisted by new biomaterials has become a hot topic in recent years,among which electrospinning biomaterials with good biocompatibility have attracted wide attention.In this paper,based on periodontal clinical problems,the importance of functional regeneration is presented and clarified.Besides,according to the application of electrospinning biomaterials reported in previous researches,their effects of promoting functional periodontal tissue regeneration are analyzed.In addition,the internal mechanism of periodontal tissue repair by electrospinning materials is discussed and the future research direction is also proposed,in order to provide a new strategy for clinical treatment of periodontal diseases.

关 键 词：牙周炎 牙周组织 静电纺丝 生物材料 牙周组织再生 

分 类 号：R781.42[医药卫生—口腔医学]