50岁及以上人群视盘周围神经纤维层横截面积与近视眼的相关性分析  

Analysis of the correlation between peripapillary retinal nerve fiber layer cross-sectional area and myopia in individuals aged 50 years and above

作　　者：延艳妮 魏文斌 Yanni Yan;Wenbin Wei(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Institute of Ophthalmology,Beijing Key Laboratory of Ophthalmology&Visual Sciences,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心、北京市眼科研究所、北京市眼科学与视觉科学重点实验室,北京100730

出　　处：《中华眼科杂志》2023年第7期550-556,共7页Chinese Journal of Ophthalmology

基　　金：国家自然科学基金(82220108017, 82141128);首都卫生发展科研专项(首发2020-1-2052);北京市科委科技计划项目(Z201100005520045, Z181100001818003)。

摘　　要：目的测量50岁及以上不同屈光度数人群视盘周围视网膜神经纤维层(RNFL)横截面积,并分析其与眼轴长度和屈光度数的相关关系。方法横断面研究,受试者来自"北京眼病研究"。该研究是一项人群为基础的纵向研究,于2001年整群抽取北京市海淀区5个社区及大兴区3个农村社区的40岁及以上人群进行调查,并于2011年对该人群进行随访。本研究收集并分析受试者2011年的随访数据,每名受试者随机选取1只眼,根据等效球镜度数分为正视眼组(-0.50 D≤等效球镜度数≤0.50 D)、低度近视眼组(-3.00 D≤等效球镜度数<-0.50 D)、中度近视眼组(-6.00 D≤等效球镜度数<-3.00 D)和高度近视眼组(等效球镜度数<-6.00 D)。受试眼均采用谱域相干光层析成像术(OCT)设备行以视盘中心为中心、以12°夹角投射线段为直径的环形扫描。分别用ImageJ软件和Heidelberg Eye Explorer软件计算法获得RNFL横截面积。单因素方差分析比较不同分组中RNFL厚度和RNFL横截面积的差异;线性回归分析法分析RNFL厚度及横截面积与眼轴长度和等效球镜度数的相关性。结果共纳入184名受试者(184只眼),其中男性88名,女性96名;年龄为59(54,66)岁;87只右眼,97只左眼。正视眼组、低度近视眼组、中度近视眼组各50人(50只眼),高度近视眼组34人(34只眼)。各组间年龄、性别和眼别分布差异均无统计学意义(均P>0.05)。正视眼组、低度近视眼组、中度近视眼组和高度近视眼组RNFL横截面积分别为(1.115±0.106)、(1.122±0.136)、(1.105±0.105)和(1.096±0.106)mm2,差异无统计学意义(F=0.43,P=0.730);RNFL厚度分别为(102.5±9.5)、(102.5±12.1)、(94.2±8.3)和(90.2±8.9)μm,差异有统计学意义(F=16.42,P<0.001)。以等效球镜度数为自变量,视盘周围RNFL厚度为因变量,做一元线性回归分析,得到回归方程为视盘周围RNFL厚度=102.651+1.634×等效球镜度数(R2=0.21,P<0.001);以眼轴长度为自变量,视�Objective To measure the peripapillary retinal nerve fiber layer(RNFL)cross-sectional area in individuals aged 50 years and above with different refractive errors,and analyze its correlation with axial length and refractive error.Methods This was a cross-sectional study conducted as part of the"Beijing Eye Study".The study was population-based and longitudinally designed.In 2001,a cohort of individuals aged 40 years and above from five urban communities in Haidian District and three rural communities in Daxing District,Beijing,were surveyed.Follow-up examinations were conducted in 2011.In this study,the follow-up data from 2011 were collected and analyzed.One eye of each participant was randomly selected,and the participants were categorized into four groups based on their spherical equivalent:emmetropia group(-0.50 D≤spherical equivalent≤0.50 D),low myopia group(-3.00 D≤spherical equivalent<-0.50 D),moderate myopia group(-6.00 D≤spherical equivalent<-3.00 D),and high myopia group(spherical equivalent<-6.00 D).Spectral-domain optical coherence tomography(OCT)was used to perform circular scans with a diameter of 12°centered on the optic disc.ImageJ software and Heidelberg Eye Explorer software were used to calculate the RNFL cross-sectional area.One-way analysis of variance was used to compare the differences in RNFL thickness and RNFL cross-sectional area among different groups.Linear regression analysis was performed to analyze the correlation between RNFL thickness and axial length and spherical equivalent,as well as the correlation between RNFL cross-sectional area and axial length and spherical equivalent.Results A total of 184 participants(184 eyes)were included in the study,including 88 males and 96 females.The median age was 59(54,66)years,with 87 right eyes and 97 left eyes.There were 50 participants(50 eyes)in the emmetropia group,low myopia group,and moderate myopia group,and 34 participants(34 eyes)in the high myopia group.There were no significant differences in age,gender,and eye laterality

关 键 词：近视 神经纤维 视盘 视网膜神经节细胞 轴长度 眼 屈光 眼 体层摄影术 光学相干 

分 类 号：R778.11[医药卫生—眼科]