气体信号分子的血红素蛋白靶点研究进展  

Research Progress on Heme Protein Targets of Gas Signaling Molecules

作　　者：李骏 宋怡菲 仪杨 马晨[1] 张黄子怡 杜琳琳 李峻宇 谢飞[1] 马雪梅[1] LI Jun;SONG Yifei;YI Yang;MA Chen;ZHANG-HUANG Ziyi;DU Linlin;LI Junyu;XIE Fei;MA Xuemei(Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学环境与生命学部,北京100124

出　　处：《生物技术进展》2023年第4期499-508,共10页Current Biotechnology

基　　金：军委后勤保障部开放研究重点项目(BHJ17L018)。

摘　　要：气体信号分子包括一氧化氮、一氧化碳和硫化氢等,在调节血管扩张、神经传递、血小板凝集、免疫、细胞增殖和线粒体呼吸等生理过程中起着至关重要的作用。已有研究表明细胞中的血红素蛋白是气体信号分子的主要受体之一,它们都有共同的辅因子——血红素。血红素由4个吡咯类亚基组成的环状结构,中心螯合了1个亚铁离子的基团,是血红蛋白、肌红蛋白、过氧化物酶、细胞色素等蛋白质的辅基,中间的亚铁离子可以和气体信号分子配位结合,广泛地参与生物体内各项生理活动。对气体信号分子作用的血红素蛋白种类以及下游通路进行了综述,以期为深入研究其作用机制提供参考。Gas signaling molecules,including nitric oxide,carbon monoxide,and hydrogen sulfide,play crucial roles in regulating physiological processes such as vasodilation,neurotransmission,platelet aggregation,immunity,cell proliferation,and mitochondrial respiration.Studies have shown that heme protein in cells is one of the main receptors of gas signal molecules,and they all have the same cofactor—heme.Heme is a ring composed of four pyrrole subunits,with a center chelating a ferrous ion group.It is a co-group of proteins such as hemoglobin,myoglobin,peroxidase and cytochrome.The intermediate ferrous ion can coordinate and bind with gas signaling molecules,widely participating in various physiological activities of organisms.In this paper,the types of heme proteins and downstream pathways involved in the action of gas signaling molecules were reviewed,with a view to providing reference for further study of their mechanisms.

关 键 词：血红素蛋白 一氧化氮 一氧化碳 硫化氢 氢气 

分 类 号：Q51[生物学—生物化学]