艾地苯醌联合多巴丝肼片及吡贝地尓缓释片治疗老年PD伴抑郁的疗效及对患者炎症因子、神经细胞因子水平的影响  

Efficacy of Idebenone combined with Levodopa and Benserazide Hydrochloride Tablets and Piribedil Sustained-release Tablets in the treatment of elderly patients with Parkinson's disease and depression and its influence on the levels of inflammatory factors and neurocytokines

作　　者：董芬芬 刘婷[1] 武岳[1] DONG Fen-fen;LIU Ting;WU Yue(Department of Neurology,Shangluo Central Hospital,Shangluo 726000,Shaanxi,CHINA)

机构地区：[1]商洛市中心医院神经内科,陕西商洛726000

出　　处：《海南医学》2023年第14期1977-1981,共5页Hainan Medical Journal

基　　金：陕西省西安市科技项目(编号:2017118SF/YX012)。

摘　　要：目的观察艾地苯醌联合多巴丝肼片及吡贝地尓缓释片治疗老年帕金森病(PD)伴抑郁的疗效,并探讨其对患者炎症因子、神经细胞因子水平的影响。方法选择2020年7月至2022年7月商洛市中心医院收治的460例老年PD伴抑郁患者进行研究,根据随机数表法分为观察组和对照组各230例。对照组患者采用多巴丝肼片及吡贝地尓缓释片治疗,观察组患者在对照组治疗的基础上联合艾地苯醌治疗,两组患者均连续治疗3个月。比较两组患者治疗3个月后的临床疗效,以及治疗前、治疗3个月后的血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1(IL-1)、神经生长因子(NGF)、脑源性神经营养因子(BDNF)水平、蒙特利尔认知评估量表(MoCA)评分(北京版)、简易精神状态检查量表(MMSE)评分、焦虑自评量表(SAS)和抑郁自评量表(SDS)评分,并记录两组患者在治疗期间不良反应的发生情况。结果观察组患者治疗后的总有效率为95.22%,明显高于对照组的90.00%,差异有统计学意义(P<0.05);治疗后,观察组患者的CRP、TNF-α、IL-6、IL-1水平分别为(5.16±0.52)mg/L、(34.93±1.60)mg/L、(42.81±5.54)pg/L、(42.06±4.59)pg/L,明显低于对照组的(7.27±1.12)mg/L、(51.78±2.83)mg/L、(64.04±5.40)pg/L、(62.86±7.91)pg/L,血清NGF、BDNF水平分别为(13.22±1.83)ng/L、(18.70±2.15)ng/L,明显高于对照组的(9.75±1.20)ng/L、(12.46±1.80)ng/L,差异均有统计学意义(P<0.05);治疗后,观察组患者的MoCA、MMSE评分分别为(24.72±2.25)分、(25.75±2.50)分,明显高于对照组的(21.30±2.17)分、(22.62±2.31)分,SAS、SDS评分分别为(43.37±3.06)分、(43.70±2.14)分,明显低于对照组的(55.12±4.92)分、(55.18±2.09)分,差异均有统计学意义(P<0.05);观察组和对照组患者的不良反应发生率分别为7.27%、14.55%,差异无统计学意义(P>0.05)。结论艾地苯醌联合多巴丝肼片及吡贝地尓缓释片治疗老年PD伴Objective To observe the therapeutic effect of Idebenone combined with Levodopa and Benserazide Hydrochloride Tablets and Piribedil Sustained-release Tablets in the treatment of elderly Parkinson's disease(PD)with depression,and to explore its impact on the levels of inflammatory factors and neurocytokines in patients.Methods A total of 460 elderly PD patients with depression admitted to Shangluo Central Hospital from July 2020 to July 2022 were selected for this study.According to the random number table method,they were divided into the observation group and the control group,with 230 cases in each group.The patients in the control group were treated with Levodopa and Benserazide Hydrochloride Tablets and Piribedil Sustained-release Tablets,and the patients in the observation group were additionally treated with Idebenone on the basis of the control group,both continuously for 3 months.The clinical efficacy at 3 months after treatment and the changes of serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1(IL-1),nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),Montreal cognitive assessment scale(MoCA)(Beijing Edition),mini-mental state examination(MMSE),self-rating anxiety scale(SAS),self-rating depression scale(SDS)scores before treatment and at 3 months after treatment between the two groups were compared.The incidence of adverse reactions during treatment between the two groups was recorded.Results The total effective rate of the observation group after treatment was 95.22%,which was significantly higher than 90.00%of the control group(P<0.05).The levels of CRP,TNF-α,IL-6,and IL-1 in the observation group after treatment were(5.16±0.52)mg/L,(34.93±1.60)mg/L,(42.81±5.54)pg/L,(42.06±4.59)pg/L,which were significantly lower than(7.27±1.12)mg/L,(51.78±2.83)mg/L,(64.04±5.40)pg/L,(62.86±7.91)pg/L in the control group;the levels of serum NGF and BDNF were(13.22±1.83)ng/L and(18.70±2.15)ng/L,which were significantly higher than(9.75±1.20)ng/L and

关 键 词：老年 帕金森 抑郁 艾地苯醌 多巴丝肼片 吡贝地尓缓释片 疗效 炎症因子 神经细胞因子 

分 类 号：R742.5[医药卫生—神经病学与精神病学]