活血通络胶囊联合卡马西平治疗原发性三叉神经痛疗效观察  

Efficacy of Huoxue Tongluo Capsule combined with carbamazepine in the treatment of primary trigeminal neuralgia

作　　者：郭强[1] 任建红 党彩艳[1] GUO Qiang;REN Jian-hong;DANG Cai-yan(Department of Pain,Xi'an Central Hospital,Xi'an 710003,Shaanxi,CHINA;First Department of Internal Medicine,Qianxian Hospital of Traditional Chinese Medicine,Xianyang 713300,Shaanxi,CHINA)

机构地区：[1]西安市中心医院疼痛科,陕西西安710003 [2]乾县中医医院内一科室,陕西咸阳713300

出　　处：《海南医学》2023年第14期2016-2020,共5页Hainan Medical Journal

基　　金：陕西省西安市科技计划项目(编号:22YXYJ0030)。

摘　　要：目的观察活血通络胶囊联合卡马西平治疗原发性三叉神经痛的临床效果。方法选择2020年3月至2022年3月西安市中心医院收治的100例原发性三叉神经痛患者进行研究,按照随机数表法分为观察组和对照组各50例。对照组患者应用卡马西平治疗,观察组患者则在此基础上联合活血通络胶囊治疗,均连续治疗20 d。比较两组患者治疗前后的视觉模拟评分法(VAS)、匹兹堡睡眠质量指数问卷(PSQI)评分、炎症指标[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-1β]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)]的变化及治疗期间的不良反应发生情况。结果治疗后,两组患者的VAS评分、PSQI评分均明显低于治疗前,且观察组患者治疗后的VAS评分、PSQI评分分别为(2.39±0.42)分、(6.59±1.13)分,明显低于对照组的(3.18±0.35)分、(8.02±1.42)分,差异均有统计学意义(P<0.05);治疗后,两组患者的TNF-α、IL-6、IL-1β均明显低于治疗前,且观察组患者治疗后的血清TNF-α、IL-6、IL-1β水平分别为(21.12±2.53)pg/mL、(17.02±2.41)pg/mL、(20.74±2.18)pg/mL,明显低于对照组的(29.05±2.84)pg/mL、(21.62±2.81)pg/mL、(27.43±2.60)pg/mL,差异均有统计学意义(P<0.05);治疗后,两组患者的MDA均明显低于治疗前,SOD、GSH-Px均明显高于治疗前,且观察组患者治疗后的血清MDA水平为(4.31±1.26)μmol/L,明显低于对照组的(5.27±1.01)μmol/L,SOD、GSH-Px水平分别为(91.35±14.21)U/mL、(69.71±8.56)U/L,明显高于对照组的(80.40±12.53)U/mL、(56.80±6.21)U/L,差异均有统计学意义(P<0.05);观察组和对照组不良反应发生率分别为14.00%、12.00%,差异无统计学意义(P>0.05)。结论活血通络胶囊联合卡马西平治疗原发性三叉神经痛能明显缓解患者疼痛,改善睡眠质量及炎症状况,降低氧化应激反应,不良反应发生率低,临床治疗效果显著,值得临床推广。Objective To observe the clinical effect of Huoxue Tongluo Capsule combined with carbamazepine in the treatment of primary trigeminal neuralgia.Methods A total of 100 patients with primary trigeminal neuralgia admitted to Xi'an Central Hospital from March 2020 to March 2022 were selected,and they were divided into an observation group and a control group according to the random number table method,with 50 cases in each group.Patients in the control group were treated with carbamazepine,while those in the observation group were treated with Huoxue Tongluo Capsule on this basis,for 20 days.The Visual Analogue Scale(VAS),Pittsburgh Sleep Quality Index Questionnaire(PSQI)score,inflammatory indicators[tumor necrosis factor-α(TNF-α),interleukin(IL)-6,IL-1β],oxidative stress indicators[malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)]before treatment and 20 days after treatment and the occurrence of adverse reactions during treatment were compared between the two groups.Results After treatment,the VAS score and PSQI score of both groups were significantly lower than those before treatment;the VAS score and PSQI score in the observation group after treatment were(2.39±0.42)points and(6.59±1.13)points,which were significantly lower than(3.18±0.35)points and(8.02±1.42)points in the control group;the differences were statistically significant(P<0.05).After treatment,the serum TNF-α,IL-6,and IL-1βlevels of both groups were significantly lower than those before treatment;the serum TNF-α,IL-6,and IL-1βlevels in the observation group after treatment were(21.12±2.53)pg/mL,(17.02±2.41)pg/mL,and(20.74±2.18)pg/mL,which were significantly lower than(29.05±2.84)pg/mL,(21.62±2.81)pg/mL,(27.43±2.60)pg/mL in the control group;the differences were statistically significant(P<0.05).After treatment,MDA levels in both groups were significantly lower than those before treatment,while SOD and GSH-Px levels were significantly higher than those before treatment;the serum MDA level in the observation

关 键 词：原发性三叉神经痛 卡马西平 活血通络胶囊 炎症因子 氧化应激 不良反应 

分 类 号：R745.11[医药卫生—神经病学与精神病学]