序贯四联疗法治疗幽门螺杆菌阳性消化性溃疡患者的效果分析  

Effect analysis of sequential quadruple therapy on patients with Helicobacter pylori-positive peptic ulcer

作　　者：郁燕 黄宇 周骁宇 YU Yan;HUANG Yu;ZHOU Xiao-yu(Department of Gastroenterology,Qidong People's Hospital/Qidong Liver Cancer Institute/Qidong Hospital Affiliated to Nantong University,Qidong 226200,China)

机构地区：[1]启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院消化内科,226200

出　　处：《中国现代药物应用》2023年第13期16-19,共4页Chinese Journal of Modern Drug Application

基　　金：南通市科技计划项目(项目编号:MSZ21102)。

摘　　要：目的分析幽门螺杆菌阳性消化性溃疡患者采用序贯四联疗法干预的临床疗效。方法60例幽门螺杆菌阳性消化性溃疡患者,按照数字随机法分为观察组与对照组,每组30例。对照组患者采用单一四联疗法进行干预,观察组患者采用序贯四联疗法进行干预。比较两组患者干预前后腹痛、腹胀、反酸、呕吐症状评分以及总分;临床疗效;干预后不良反应发生情况;抗幽门螺杆菌治疗2周后复查幽门螺杆菌转阴情况。结果干预后,观察组腹痛、腹胀、反酸、呕吐症状评分以及总分分别为(1.03±0.51)、(1.15±0.81)、(2.06±0.55)、(3.16±0.45)、(7.61±1.58)分,均低于对照组的(3.01±1.32)、(2.88±1.03)、(3.51±0.51)、(3.59±0.55)、(12.89±3.11)分,差异均具有统计学意义(P<0.05)。观察组治疗总有效率93.33%高于对照组的73.33%,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率16.67%低于对照组的40.00%,差异具有统计学意义(P<0.05)。对照组抗幽门螺杆菌治疗2周后复查幽门螺杆菌阳性8例,阴性22例,转阴率73.33%;观察组抗幽门螺杆菌治疗2周后复查幽门螺杆菌阳性2例,阴性28例,转阴率93.33%。观察组抗幽门螺杆菌治疗2周后复查幽门螺杆菌转阴率高于对照组,差异具有统计学意义(P<0.05)。结论对幽门螺杆菌阳性消化性溃疡患者采用序贯四联疗法进行干预可以更为科学有效地降低患者治疗中药物不良反应发生率,具有较为有效的临床疗效指征。Objective To analyze the clinical efficacy and drug resistance of sequential quadruple therapy on patients with Helicobacter pylori-positive peptic ulcer.Methods A total of 60 patients with Helicobacter pylori-positive peptic ulcer were randomly divided into observation group and control group,with 30 cases in each group.The control group was intervened with quadruple therapy,and the observation group was intervened with sequential quadruple therapy.Both groups were compared in terms of scores of abdominal pain,abdominal distension,acid reflux and vomiting and total score before and after the intervention,clinical efficacy,incidence of adverse reactions after intervention,negative-conversion of Helicobacter pylori after 2 weeks of anti-Helicobacter pylori therapy.Results After the intervention,the scores of abdominal pain,abdominal distension,acid reflux,vomiting and total score were(1.03±0.51),(1.15±0.81),(2.06±0.55),(3.16±0.45)and(7.61±1.58)points in the observation group,which were lower than those of(3.01±1.32),(2.88±1.03),(3.51±0.51),(3.59±0.55)and(12.89±3.11)points in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment of 93.33%in the observation group was higher than that of 73.33%in the control group,and the difference was statistically significant(P<0.05).The incidence rate of adverse reactions was 16.67%in the observation group,which was lower than that of 40.00%in the control group,and the difference was statistically significant(P<0.05).In the control group,8 cases were positive and 22 cases were negative after 2 weeks of anti-Helicobacter pylori therapy;in the observation group,2 cases were positive and 28 cases were negative after 2 weeks of anti-Helicobacter pylori therapy.The rate of negative-conversion of Helicobacter pylori in the observation group after 2 weeks of anti-Helicobacter pylori therapy was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Sequential quadrup

关 键 词：消化性溃疡 序贯疗法 四联疗法 幽门螺杆菌 临床疗效 

分 类 号：R573.1[医药卫生—消化系统]