淋巴细胞亚群检测在血液肿瘤中应用的专家共识  

Consensus of experts on the application of lymphocyte subsets in hematologic malignancies

作　　者：中国医药质量管理协会医学检验质量管理专业委员会 杨再林 武坤 刘耀 陈双 程沈菊 蒋亭亭 李轶勋 彭余 Professional Committee of Medical Laboratory Quality Management of China Quality Association for Pharmaceuticals

机构地区：[1]不详 [2]重庆大学附属肿瘤医院 [3]昆明医科大学第一附属医院

出　　处：《国际检验医学杂志》2023年第15期1793-1802,共10页International Journal of Laboratory Medicine

基　　金：中央高校基本科研业务费(2022CDJYGRH-001);重庆市科卫联合医学科研项目(2021MSXM272);云南省科技厅科技计划项目(202201AY070001-058)。

摘　　要：血液肿瘤是起源于造血系统的恶性肿瘤,其发病机制复杂,环境因素、遗传因素、免疫因素等都被认为与疾病的发生、进展密切相关。淋巴细胞亚群中的T淋巴细胞、B淋巴细胞、自然杀伤淋巴细胞及淋巴细胞功能亚群调节性T细胞是细胞免疫检测的常用指标,广泛用于血液肿瘤患者的免疫状态评估、疾病复发或转移风险预测及治疗指导等。为了更加深刻认识淋巴细胞亚群检测在血液肿瘤中的作用,加强其检测过程的质量管理,促进其规范地应用于临床,由中国医药质量管理协会医学检验质量管理专业委员会牵头组织国内血液肿瘤和临床检验领域多位专家,制定了该专家共识。该共识介绍了淋巴细胞亚群的检测方法,归纳总结了其对血液肿瘤筛查、复发转移预警及预后评估、合并感染风险预警、造血干细胞移植后免疫重建监测与移植物抗宿主病预防、嵌合抗原受体T细胞免疫治疗后监测、用药指导与疗效监测等方面的应用,并对血液肿瘤患者的监测方案与随访时机选择做出了推荐。Hematologic malignancies originate from the hematopoietic system with complex pathogenesis.The factors of environment,gene and immunity are considered to be closely related to the occurrence and progression of the tumors.Lymphocyte subsets of T lymphocyte,B lymphocyte,natural killer cells and regulatory T cells are commonly detected in clinical laboratory to evaluate immune status,predict the risk of tumor recurrence or metastasis and guide treatments for patients.In order to deeply understand the role of lymphocyte subsets detection,strengthen the quality management in the detection process,and promote the standardized applications in hematologic malignancies,a number of domestic experts in the field of hematology-oncology and clinical laboratory were organized by the Professional Committee of Medical Laboratory Quality Management of China Quality Association for Pharmaceuticals to formulate this expert consensus.This consensus describes the methods of lymphocyte subsets detection,and the applications of lymphocyte subsets in hematologic malignancies for screening,recurrence,metastasis,prognosis assessment,infection,hematopoietic stem cell transplantation,graft-versus-host disease,chimeric antigen receptor T cell immunotherapy,drug guidance and monitor.

关 键 词：淋巴细胞亚群 T淋巴细胞 B淋巴细胞 自然杀伤细胞 调节性T细胞 流式细胞术 免疫 血液肿瘤 

分 类 号：R733[医药卫生—肿瘤]