泛连接蛋白1参与炎症调控及细胞焦亡的研究进展  

Progress in pannexin 1 involved in inflammation regulation and pyroptosis

作　　者：马源 段倩雯 董旭鹏 刘澈 马玉清[2] MA Yuan;DUAN Qianwen;DONG Xupeng;LIU Che;MA Yuqing(The First School of Clinical Medicine of Lanzhou University,Lanzhou 730000,China;Department of Anesthesiology,The First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院麻醉科,甘肃兰州730000

出　　处：《中国病理生理杂志》2023年第7期1318-1323,共6页Chinese Journal of Pathophysiology

基　　金：甘肃省自然科学基金资助项目(No.21JRIRA077)。

摘　　要：1泛连接蛋白1(pannexin 1,Panx1)通道及其调控1.1 Panx1概况Panx1作为泛连接蛋白家族成员之一,激活后可在细胞膜上形成通道,释放10 kD以内的物质于细胞外,如腺苷三磷酸(adenosine triphos⁃phate,ATP)、尿苷三磷酸(uridine triphosphate,UTP)、K+和Ca2+等。细胞内物质作为炎症介质,经Panx1释放到细胞外,诱导失控性炎症反应发生[1]。Pannexin 1(Panx1),a member of the ubiquitin family,is widely expressed in mammalian tissues.When the body is in an inflammatory state,Panx1 channel is activated and opened by high concentration of ion stimulation,caspase shearing,tyrosine phosphorylation and mechanical stretching pathway,which allows intracellular ATP to be released outside the cell and aggravates inflammatory response.Panx1 is also involved in the occurrence of pyroptosis in inflammatory response,and activates and releases a large number of interleukin-1-related inflammatory factors.Inflammatory response is the body's defense response to infection,but overexpression of Panx1 leads to uncontrolled inflammatory response.Therefore,Panx1,as a new intervention target of inflammation,has certain research value and application prospect.

关 键 词：泛连接蛋白1 炎症 细胞焦亡 胱天蛋白酶 白细胞介素1Β 

分 类 号：R363[医药卫生—病理学] R329.28[医药卫生—基础医学]