IL-17、IL-12p70在宫颈癌组织中的表达及与临床病理特征和预后的关系  

Expression of IL⁃17 and IL⁃12p70 in cervical cancer tissues and their correlation with clinicopathological features and prognosis

作　　者：徐双喜 朱长东 朱成苗[1,2] 王相岩 XU Shuangxi;ZHU Changdong;ZHU Chengmiao;WANG Xiangyan(Department of Blood Transfusion,Lujiang County People’s Hospital,Lujiang,Anhui,China,231500;Department of Gynecology,Chaohu Hospital Affiliated to Anhui Medical University,Chaohu,Anhui,China,238000)

机构地区：[1]安徽省庐江县人民医院输血科,安徽庐江231500 [2]安徽医科大学附属巢湖医院妇科,安徽巢湖238000

出　　处：《分子诊断与治疗杂志》2023年第7期1160-1163,1168,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省重点研究与开发计划项目(1704f0804023)。

摘　　要：目的 探讨白细胞介素-17(IL-17)、IL-12p70在宫颈癌组织中的表达及与临床病理特征和预后的关系。方法 选取2015年1月至2017年12月于安徽省庐江县人民医院接受根治术的宫颈癌患者106例作为研究对象,收集患者宫颈癌组织与癌旁组织,检测宫颈癌组织与癌旁组织中的IL-17、IL-12p70表达;分析宫颈癌组织中IL-17、IL-12p70表达与患者临床病理特征与预后的关系。结果与癌旁组织中IL-17、IL-12p70表达比较,宫颈癌组织中IL-17、IL-12p70表达阳性率显著高于癌旁组织,差异具有统计学意义(t=14.840、4.255,P<0.05);Ⅲ期与有淋巴结转移患者的IL-17表达阳性率高于TNM分期Ⅰ、Ⅱ期、无淋巴结转移患者(χ^(2)=8.664、6.569,P<0.05),Ⅲ期与有淋巴结转移患者的IL-12p70表达阳性率低于TNM分期Ⅰ、Ⅱ期、无淋巴结转移患者(χ^(2)=10.424、8.880,P<0.05);IL-17表达阳性、阴性宫颈癌患者5年生存率分别为50.00%、83.33%,差异具有统计学意义(χ^(2)=11.137,P<0.05);IL-12p70表达阳性、阴性宫颈癌患者5年生存率分别为77.78%、37.21%,差异具有统计学意义(χ^(2)=17.734,P<0.05)。结论宫颈癌组织中IL-17、IL-12p70表达水平均升高,两项指标均与病理分期、淋巴结转移以及预后有关。Objective To investigate the expression of interleukin⁃17(IL⁃17),IL⁃12p70 in cervi⁃cal cancer tissues and the relationship with clinicopathological characteristics and prognosis.Methods A total of 106 cervical cancer patients who underwent radical surgery in Lujiang County People's Hospital of Anhui Province between January 2015 and December 2017 were selected as the study subjects,and the cervical can⁃cer tissues and paracancerous tissues from the patients were collected to detect the IL⁃17,IL⁃12p70 expres⁃sion;The expression of IL⁃17 and IL⁃12p70 in cervical cancer tissues was analyzed to correlate with clinico⁃pathological characteristics and prognosis of patients.Results Compared with the expression of IL⁃17 and IL⁃12p70 between cervical cancer tissues and adjacent non⁃cancerous tissues,the expression of IL⁃17 and IL⁃12p70 in cervical cancer tissues was significantly higher than that in adjacent non⁃cancerous tissues,with significant differences(t=14.840,4.255,P<0.05).The positive rate of IL⁃17 expression in stageⅢversus pa⁃tients with lymph node metastasis was higher than that in TNM stageⅠorⅡversus patients without lymph node metastasis(χ^(2)=8.664,6.569,P<0.05),and the positive rate of IL⁃12p70 expression in stageⅢversus patients with lymph node metastasis was lower than that in TNM stageⅠ,Ⅱversus patients without lymph node metastasis(χ^(2)=10.424,8.880,P<0.05).The 5⁃year survival rates of patients with positive and negative IL⁃17 expression were 50.00%and 83.33%,respectively(χ^(2)=11.137,P<0.05).The 5⁃year survival rates of pa⁃tients with positive and negative IL⁃12p70 expression were 77.78%and 37.21%,respectively(χ^(2)=17.734,P<0.05).Conclusion The expression levels of IL⁃17 and IL⁃12p70 were increased in cervical cancer tissues,and both indicators were associated with pathological stage,lymph node metastasis and prognosis.

关 键 词：白细胞介素⁃17 IL⁃12p70 宫颈癌 临床病理特征 

分 类 号：R737.33[医药卫生—肿瘤]