粪便FC蛋白联合血清CA125、CRP对溃疡性结肠炎患者的预后评估  

The value of fecal FC protein combined with serum CA125 and CRP in predicting prognosis of patients with ulcerative colitis

作　　者：孙邦英 姜文[1] 程红宇 孙海 陈新峰 钱少华 方铭慧 SUN Bangying;JIANG Wen;CHENG Hongyu;SUN Hai;CHEN Xinfeng;QIAN Shaohua;FANG Minghui(Department of Gastroenterology,Huangshan Shoukang Hospital,Huangshan,Anhui,China,245000;Department of Gastroenterology,Huangshan Huize Hospital of Integrated Traditional Chinese and Western Medicine,Huangshan,Anhui,China,245000)

机构地区：[1]黄山首康医院消化内科,安徽黄山245000 [2]黄山华泽中西医结合医院消化科,安徽黄山245000

出　　处：《分子诊断与治疗杂志》2023年第7期1207-1211,共5页Journal of Molecular Diagnostics and Therapy

基　　金：黄山市科技计划项目任务书(2022KN⁃09)。

摘　　要：目的探讨粪便钙卫蛋白(FC)联合血清糖类抗原(CA)125、C反应蛋白(CRP)对溃疡性结肠炎(UC)患者预后的预测价值。方法选取2017年1月至2022年2月黄山首康医院收治的UC患者82例为研究对象,根据病情严重程度分为轻度组(n=21)、中度组(n=34)和重度组(n=27)。比较三组基线粪便FC蛋白及血清CA125、CRP水平,分析三者与UC患者病情严重程度和预后的关系及三者联合检测的UC患者预后早期预测效能。结果三组粪便FC蛋白及血清CA125、CRP水平比较,轻度组<中度组<重度组(F=67.262,64.264,79.080,均P<0.001)。粪便FC蛋白及血清CA125、CRP水平与UC病情严重程度均呈正相关(r=0.826,0.683,0.771,均P<0.001)。不良组年龄、病程、重度患者比例、粪便FC蛋白及血清CA125、CRP水平均高于良好组(均P<0.05)。患者粪便FC蛋白及血清CA125、CRP水平均为UC患者不良预后的危险因素(均P<0.05),且三者联合应用的UC患者预后早期预测效能最佳[AUC(95%CI)=0.996(0.988~1.000)]。结论粪便FC蛋白、血清CA125、CRP水平在UC患者中均较高,且与其病情和预后均相关,可作为UC病情和预后早期评估参考指标。Objective To explore the value of fecal calprotectin(FC)protein combined with se rum carbohydrate antigen(CA)125 and C⁃reactive protein(CRP)in predicting prognosis of patients with ul⁃cerative colitis(UC).Methods 82 patients with UC admitted from January 2017 to February 2022 were se⁃lected as the study subjects.The patients were divided into the mild group(n=21),the moderate group(n=34)and the severe group(n=27)according to the severity of the disease.The levels of FC protein in stool and serum CA125 and CRP in the three groups at baseline were compared.The relationship between the levels of the 3 factors with the disease severity and adverse prognosis of the UC,and the value of the 3 factors in combi⁃nation for early prognosis prediction of UC patients were analyzed.Results Comparing of the levels of FC protein in stool and serum CA125 and CRP in the three groups,mild group<moderate group<severe group(F=67.262,64.264,79.080,P<0.001).The levels of FC protein in stool and serum CA125 and CRP were positively correlated with the severity of UC(r=0.826,0.683,0.771,P<0.001).The age,course of disease,proportion of severe patients,fecal FC protein,serum CA125 and CRP levels in the adverse group were high⁃er than those in the good group(P<0.05).FC protein in stool and serum CA125 and CRP levels were risk fac⁃tors for poor prognosis in UC patients(P<0.05),and the combination of the 3 factors in UC patients had the best early prognosis prediction effect[AUC(95%CI)=0.996(0.988~1.000)].Conclusion The levels of FC protein in stool,serum CA125 and CRP are higher in patients with UC,and all of them are related to patients'disease severity and prognosis.They can be used as reference indicators for early evaluation of the disease se⁃verity and prognosis of UC patients.

关 键 词：粪便钙卫蛋白 糖类抗原125 C反应蛋白 溃疡性结肠炎 预后评估 

分 类 号：R574.62[医药卫生—消化系统]