伴自杀倾向的住院抑郁障碍患者临床特征分析  

Analysis of clinical characteristics of inpatients with depressive disorder and suicidal tendencies

作　　者：朱丹迪 潘伟刚[1,2] 刘超猛 刘毅 任莉 任艳萍[1,2] 马辛[1,2] Zhu Dandi;Pan Weigang;Liu Chaomeng;Liu Yi;Ren Li;Ren Yanping;Ma Xin(Beijing Key Laboratory of Mental Disorders,National Clinical Research Center for Mental Disorders&National Center for Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京安定医院国家精神疾病医学中心、国家精神心理疾病临床医学研究中心、精神疾病诊断与治疗北京市重点实验室,100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069

出　　处：《神经疾病与精神卫生》2023年第7期468-472,共5页Journal of Neuroscience and Mental Health

基　　金：北京市科技计划项目(D171100007017001)。

摘　　要：目的 探讨住院抑郁障碍患者自杀倾向的相关因素。方法 选取2017年11月至2018年12月在首都医科大学附属北京安定医院住院治疗的1 160例抑郁障碍患者为研究对象,按照有无自杀倾向(包括自杀观念与自杀未遂)将其分为自杀倾向组(n=431)和无自杀倾向组(n=729)。比较两组患者的临床特征,采用二项Logistic回归分析住院抑郁障碍患者自杀倾向的相关因素。结果 单因素分析显示,两组患者的性别、冲动性格、精神活性物质依赖史、自杀家族史、重大精神创伤史、抑郁严重程度比较,差异有统计学意义(χ^(2)=5.841、33.806、5.869、5.585、5.499、33.311;P<0.05)。二项Logistic回归分析显示,冲动性格(OR=2.445,95%CI=1.802~3.319)、有精神活性物质依赖史(OR=2.254,95%CI=1.038~4.894)、有重大精神创伤史(OR=1.533,95%CI=1.056~2.226)、抑郁症状严重程度较重(OR=2.754,95%CI=2.002~3.790)是住院抑郁障碍患者自杀倾向的影响因素(P<0.05)。结论 冲动性格、精神活性物质依赖史、重大精神创伤史、严重的抑郁症状可能增加住院抑郁障碍患者的自杀倾向。Objective To explore the relevant factors of suicidal tendencies among inpatients with major depressive disorder.Methods A total of 1160 patients with depressive disorder who were hospitalized in Beijing Anding Hospital affiliated to Capital Medical University from November 2017 to December 2018 were selected as subjects and divided into suicide group(n=431)and non-suicide group(n=729)according to suicidal tendencies(including suicidal ideation and attempted suicide).The clinical characteristics of the two groups were compared,and the binary logistic regression analysis was used to explore the relevant factors of suicidal tendencies among inpatients with major depressive disorder.Results Univariate analysis showed that there were statistically significant differences between the two groups in terms of gender,impulsive personality,history of psychoactive substance dependence,family history of suicide,history of major mental trauma,and severity of depression(x^(2)=5.841,33.806,5.869,5.585,5.499,33.311,respectively;P<0.05).Binary Logistic regression analysis revealed that impulsive personality(0R=2.445,95%CI:1.802-3.319),history of psychoactive substance dependence(OR=2.254,95% CI:1.038-4.894),history of major mental trauma(0R=1.533,95% CI:1.056-2.226),and severity of depression(OR=2.754,95% CI:2.002-3.790)were the influencing factors for suicidal tendencies of inpatients with depressive disorders.Conclusions Impulsive personality,history of psychoactive substance dependence,history of major trauma,and major depressive symptoms may increase suicidal tendencies among inpatients with depressive disorders.

关 键 词：抑郁症 住院 自杀倾向 临床特征 

分 类 号：R749.4[医药卫生—神经病学与精神病学]