β-catenin在牙发育调控中的研究进展  

Research progress ofβ-catenin in tooth development

作　　者：隋昕 杜仲 SUI Xin;DU Zhong(Department of Endodontics,Shanghai Stomatological Hospital&School of Stomatology,Fudan University,Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases,Fudan University,Shanghai 200031;Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai Research Institute of Stomatology,Shanghai 200011,China)

机构地区：[1]上海市口腔医院牙体牙髓病科,上海市颅颌面发育与疾病重点实验室,上海200031 [2]上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海200011

出　　处：《中国口腔颌面外科杂志》2023年第4期413-417,共5页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(82201085)。

摘　　要：β-catenin是经典Wnt信号通路的核心分子,其在牙的发生发育中发挥重要的调控作用。本文从β-catenin在牙发育过程中的表达分布特点以及在牙发生、牙冠发育、牙根形成中的作用机制等方面,对近年来的相关研究进展进行综述,以期为阐明牙发育机制、探索牙发育相关疾病的潜在治疗靶点以及精准调控牙再生提供新的思路。β-catenin is the central hub in the canonical Wnt/β-catenin signaling pathway,which plays an important role in the regulation of odontogenesis and tooth development.In this paper,we reviewed the recent research progress in terms of the expression pattern ofβ-catenin during tooth development,the molecular mechanism ofβ-catenin in tooth development process which includes odontogenesis,crown development and root formation.It may provide a reference for elucidation of tooth development mechanism,exploration of potential therapeutic targets of tooth development related diseases,and precise regulation of tooth regeneration.

关 键 词：Β-CATENIN WNT/Β-CATENIN信号通路 牙发育 牙根形成 

分 类 号：R78[医药卫生—口腔医学]