输精管结扎术对前列腺癌发生风险系统评价/Meta分析的再评价  

Re-evaluation of systematic evaluation and Meta-analysis of Vasectomy for prostate cancer risk

作　　者：李松兰 王国蓉[2] 王璐杉 姚丹 邢乃芳 LI Songlan;WANG Guorong;WANG Lushan;YAO Dan;XING Naifang(Nursing College of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China;Department of Nursing,Sichuan Cancer Hospital,Chengdu 610042,Sichuan,China)

机构地区：[1]成都中医药大学护理学院,四川成都610075 [2]四川省肿瘤医院护理部,四川成都610042

出　　处：《中国现代医生》2023年第20期105-111,共7页China Modern Doctor

摘　　要：目的对于输精管结扎术对前列腺癌发生风险相关系统评价/Meta分析进行再评价,明确输精管结扎术对前列腺癌的发生风险,为输精管结扎临床决策提供依据。方法系统检索中国知网、万方、维普、中国生物医学数据库、Pub Med、Embase、Medline、Web of Science、Cochrane Library等常用数据库,检索建库以来至2022年7月5日公开发表的相关系统评价/Meta分析相关文献。采用PRISMA声明评价纳入研究报告质量,通过系统评价方法学质量评价工具AMSTAR2量表对评价方法学质量进行评估,通过GRADE证据质量评价对证据等级进行评估。结果共纳入15篇系统评价/Meta分析相关文献,PRISMA得分为11.5~24.5分,在方案和注册、研究偏倚、其他分析、资金等方面存在不足;AMSTAR2量表评价结果提示纳入研究方法学质量偏低;GRADE证据质量评价共纳入35个结局指标,均为低级证据。结论综合考虑现有证据及Meta分析结果,提示前列腺癌与输精管结扎术间不存在显著相关性,输精管结扎术可作为安全避孕方式进行选择。但纳入研究在方法学及结局指标上质量不高,以上结论虽能提供一定参考,但仍需大型的高质量研究进行验证。Objective To re-evaluate the systematic evaluation/Meta analysis of the risk associated with vasectomy for prostate cancer,to determine the risk of vasectomy for prostate cancer,and to provide basis for clinical decision-making of vasectomy.Methods Systematic search of CNKI,Wanfang,VIP,CBM,Embase,Medline,Web of Science,Cochrane Library and other commonly used Chinese and English databases,searched for relevant systematic evaluations/Meta-analyses published publicly since the database was built up to 5 July 2022,and evaluated the quality of included study reports with PRISMA statement,evaluated methodological quality with AMSTAR 2 scale,and assessed the evidence level the GRADE system.Results A total of 15 systematic evaluation/Meta-analysis were included,and PRISMA scores were 11.5-24.5.There were deficiencies in protocol and registration,research bias,other analysis,and funding.AMSTAR 2 suggested that the quality of methodology for inclusion in the study was low;and 35 outcome indicators were included in the GRADE evidence quality grading,all of which were low-level evidence.Conclusion Considering the existing evidence and Meta-analysis results,there is no significant correlation between the occurrence of prostate cancer and vasectomy,vasectomy can be used as a safe contraceptive method.However,the quality of the included studies in terms of methodology and outcome indicators is not high.Although the above conclusions can provide some reference,they still need to be verified by large-scale high-quality studies.

关 键 词：输精管结扎术 前列腺癌 系统评价 META分析 再评价 

分 类 号：R737[医药卫生—肿瘤]