二氢杨梅素神经保护作用研究进展  

Advances in neuroprotective effects of dihydromyricetin

作　　者：龙俊鹏 孙洋 刘莎莎 姚娇 阳松威 杨岩涛[1,2] 裴刚 艾启迪[1,2] 陈乃宏 LONG Jun-peng;SUN Yang;LIU Sha-sha;YAO Jiao;YANG Song-wei;YANG Yan-tao;PEI Gang;AI Qi-di;CHEN Nai-hong(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces,Changsha 410208,China;Xiangtan Central Hospital,Xiangtan,Hunan 411199,China;Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南省中药饮片标准化及功能工程技术研究中心,湖南长沙410208 [3]湘潭市中心医院,湖南湘潭411199 [4]中国医学科学院药物研究所,北京协和医学院药物研究所,北京100050

出　　处：《中国药理学通报》2023年第8期1422-1425,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 82174271);湖南省自然科学基金项目(No 2021JJ30512);湖南乾坤生物科技有限公司莓茶资源综合利用科技专项计划(No 212010);湖南省科技厅优秀青年项目(No 21B0354);长沙市自然科学基金(No kq2202269);湖南中医药大学生物工程重点学科([2018]No 3)。

摘　　要：二氢杨梅素(dihydromyricetin,DHM)是广泛存在于葡萄科蛇葡萄属植物中的一种二氢黄酮类化合物,具有抗炎、抗菌、抗肿瘤、抗氧化、调血糖、降血脂、肝保护等多种药理作用。近年的研究表明,DHM具有很好的神经保护作用,对多种神经系统病变包括阿尔茨海默病、抑郁症、帕金森综合征、脑卒中等均能起到一定的药理作用。该文针对近十年国内外对DHM的神经保护作用的相关研究进行综述,旨在为DHM的神经保护作用研究提供思路。Dihydromyricetin is a dihydroflavone compound which widely exists in ampelopsis of grapevine family.It has many pharmacological effects,such as anti-inflammatory,antibacterial,anti-tumor,antioxidant,regulating blood glucose,reducing blood lipid,liver protection and so on.In recent years,it has been found that dihydromyricetin has a good neuroprotective effect and can play a certain pharmacological role in a variety of neurological diseases,including Alzheimer′s disease,depression,Parkinson′s disease and stroke.The purpose of this paper is to review the research on the neuroprotective effect of dihydromyricetin in the past decade.

关 键 词：二氢杨梅素 神经保护 研究进展 阿尔茨海默病 脑卒中 

分 类 号：R-05[医药卫生] R284.1R322.8R743.3R745.7