药物洗脱微球-肝动脉化疗栓塞术联合微波消融治疗原发性肝癌对肝功能指标和CRP、TNF-α的影响  

Effect of Drug Eluting Beads-transcatheter Arterial Chemoembolization Combined with Microwave Ablation on Liver Function and Levels of CRP and TNF-αin Primary Liver Cancer

作　　者：李海霞[1] 王秀香[1] 王明月 李辉 LI Haixia;WANG Xiuxiang;WANG Mingyue;LI Hui(Cangzhou Infectious Diseases Hospital,Cangzhou 061001,China;不详)

机构地区：[1]沧州市传染病医院,河北沧州061001

出　　处：《中外医学研究》2023年第20期168-172,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究药物洗脱微球-肝动脉化疗栓塞术(DEB-TACE)联合微波消融治疗原发性肝癌对肝功能和C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)的影响。方法:选择2020年6月—2021年4月在沧州市传染病医院进行诊断并治疗的80例原发性肝癌患者作为研究对象,采用信封法随机分为观察组和对照组,各40例。观察组采取DEB-TACE联合微波消融治疗,对照组采取肝动脉化疗栓塞术(TACE)联合微波消融治疗,两组均由同一个医疗团队完成手术治疗。比较两组降期成功率、肝功能指标、CRP、TNF-α的差异。结果:观察组降期成功率为82.50%,显著高于对照组的60.00%,差异有统计学意义(P<0.05)。治疗后,两组谷丙转氨酶(ALT)、谷草转氨酶(AST)和总胆红素(TBIL)均低于治疗前,且观察组ALT、AST、TBIL显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CRP、TNF-α水平均低于治疗前,且观察组CRP、TNF-α水平显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组癌抗原125(CA125)、细胞角蛋白19片段抗原(CYFRA21-1)、癌胚抗原(CEA)均低于治疗前,且观察组CA125、CYFRA21-1及CEA显著低于对照组,差异有统计学意义(P<0.05)。两组发热及肝区疼痛等不良反应发生率比较,差异无统计学意义(P>0.05)。结论:原发性肝癌患者采用DEB-TACE治疗,对患者的肝功能影响较小,可明显降低CRP、TNF-α水平,治疗效果显著。Objective:To explore the effect of drug eluting beads-transcatheter arterial chemoembolization(DEB-TACE)combined with microwave ablation on liver function,C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)in the treatment of primary liver cancer.Method:A total of 80 patients with primary liver cancer who were diagnosed and treated in Cangzhou Infectious Diseases Hospital from June 2020 to April 2021 were selected as the study subjects,and they were randomly divided into observation group and control group by envelope method,with 40 patients in each group.The observation group received DEB-TACE combined with microwave ablation treatment,while the control group received transcatheter arterial chemoembolization(TACE)combined with microwave ablation treatment.Both groups underwent surgical treatment by the same medical team.The success rate of descending phase,liver function indicators,CRP,TNF-αof the two groups were compared.Result:The success rate of descent in the observation group was 82.50%,which was higher than 60.00%in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of alanine transaminase(ALT),aspartate transaminase(AST)and total bilirubin(TBIL)in the two groups were lower than those before treatment,and the ALT,AST and TBIL in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of CRP and TNF-αin both groups were all lower than those before treatment,and the CRP and TNF-αlevels in the observation group were also lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of cancer antigen 125(CA125),cell keratin 19 fragment antigen(CYFRA21-1),carcinoembryonic antigen(CEA)were lower than those before treatment,and the CA125,CYFRA21-1 and CEA in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).There

关 键 词：原发性肝癌 药物洗脱微球-肝动脉化疗栓塞术 肝功能 C反应蛋白 肿瘤坏死因子-α 

分 类 号：R735.7[医药卫生—肿瘤]